Sökning: onr:"swepub:oai:DiVA.org:uu-231244" >
Validation of insul...
Validation of insulin sensitivity surrogate indices and prediction of clinical outcomes in individuals with and without impaired renal function
-
- Jia, Ting (författare)
- Karolinska Institutet
-
- Huang, Xiaoyan (författare)
- Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden ; Division of Nephrology, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.
-
- Qureshi, Abdul R. (författare)
- Karolinska Institutet
-
visa fler...
-
- Xu, Hong (författare)
- Karolinska Institutet
-
- Ärnlöv, Johan (författare)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Medicinsk vetenskap,Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden
-
- Lindholm, Bengt (författare)
- Karolinska Institutet
-
- Cederholm, Tommy (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
-
- Stenvinkel, Peter (författare)
- Karolinska Institutet
-
- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
-
- Carrero, Juan J. (författare)
- Karolinska Institutet
-
visa färre...
-
Karolinska Institutet Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden ; Division of Nephrology, Peking University Shenzhen Hospital, Peking University, Shenzhen, China (creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
-
Ingår i: Kidney International. - : Elsevier BV. - 0085-2538 .- 1523-1755. ; 86:2, s. 383-391
- Relaterad länk:
-
http://www.kidney-in...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- As chronic kidney disease (CKD) progresses with abnormalities in glucose and insulin metabolism, commonly used insulin sensitivity indices (151s) may not be applicable in individuals with CKD. Here we sought to validate surrogate ISls against the glucose disposal rate by the gold-standard hyperinsulinemic euglycemic glucose clamp (HEGC) technique in 1074 elderly men of similar age (70 years) of whom 495 had and 579 did not have CKD (estimated glomerular filtration rate (eGFR) under 60 ml/min per 1.73 m2 (median eGFR of 46 ml/min per 1.73 m2)). All ISls provided satisfactory (weighted K over 0.6) estimates of the glucose disposal rate in patients with CKD. ISls derived from oral glucose tolerance tests (OGTTs) agreed better with HEGC than those from fasting samples (higher predictive accuracy). Regardless of CKD strata, all ISls allowed satisfactory clinical discrimination between the presence and absence of insulin resistance (glucose disposal rate under 4 mg/kg/min). We also assessed the ability of both HEGC and ISls to predict all-cause and cardiovascular mortality during a 10-year follow-up. Neither HEGC nor ISIs independently predicted mortality. Adjustment for renal function did not materially change these associations. Thus, ISls can be applied in individuals with moderately impaired renal function for diagnostic purposes. For research matters, OGTT-derived ISls may be preferred. Our data do not support the hypothesis of kidney function mediating insulin sensitivity (I5)-associated outcomes nor a role for IS as a predictor of mortality
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- chronic kidney disease
- clinical outcome
- hyperinsulinemic
- euglycemic glucose clamp
- insulin resistance
- insulin sensitivity index
- mortality
- Hälsa och välfärd
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jia, Ting
-
Huang, Xiaoyan
-
Qureshi, Abdul R ...
-
Xu, Hong
-
Ärnlöv, Johan
-
Lindholm, Bengt
-
visa fler...
-
Cederholm, Tommy
-
Stenvinkel, Pete ...
-
Risérus, Ulf
-
Carrero, Juan J.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Kidney Internati ...
- Av lärosätet
-
Uppsala universitet
-
Högskolan Dalarna
-
Karolinska Institutet