Sökning: onr:"swepub:oai:DiVA.org:uu-231328" > Large-Scale Genome-...
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000 | 06858naa a2201297 4500 | |
001 | oai:DiVA.org:uu-231328 | |
003 | SwePub | |
008 | 140907s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2313282 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01007762 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tang, Wenbo4 aut |
245 | 1 0 | a Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function |
264 | c 2014-07-01 | |
264 | 1 | b Public Library of Science (PLoS),c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. Results: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 x 10(-7)). In addition, meta-analysis using the five cohorts with >= 3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 x 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. Conclusions: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
700 | 1 | a Kowgier, Matthew4 aut |
700 | 1 | a Loth, Daan W.4 aut |
700 | 1 | a Artigas, Maria Soler4 aut |
700 | 1 | a Joubert, Bonnie R.4 aut |
700 | 1 | a Hodge, Emily4 aut |
700 | 1 | a Gharib, Sina A.4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Ruczinski, Ingo4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Mathias, Rasika A.4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Hansel, Nadia N.4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Barnes, Kathleen C.4 aut |
700 | 1 | a Hansen, Joyanna G.4 aut |
700 | 1 | a Albrecht, Eva4 aut |
700 | 1 | a Aldrich, Melinda C.4 aut |
700 | 1 | a Allerhand, Michael4 aut |
700 | 1 | a Barr, R. Graham4 aut |
700 | 1 | a Brusselle, Guy G.4 aut |
700 | 1 | a Couper, David J.4 aut |
700 | 1 | a Curjuric, Ivan4 aut |
700 | 1 | a Davies, Gail4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Dupuis, Josee4 aut |
700 | 1 | a Fall, Toveu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878 |
700 | 1 | a Foy, Millennia4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Gao, Wei4 aut |
700 | 1 | a Glaeser, Sven4 aut |
700 | 1 | a Gu, Xiangjun4 aut |
700 | 1 | a Hancock, Dana B.4 aut |
700 | 1 | a Heinrich, Joachim4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Imboden, Medea4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
700 | 1 | a James, Alan4 aut |
700 | 1 | a Karrasch, Stefan4 aut |
700 | 1 | a Koch, Beate4 aut |
700 | 1 | a Kritchevsky, Stephen B.4 aut |
700 | 1 | a Kumar, Ashish4 aut |
700 | 1 | a Lahousse, Lies4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Lindgren, Cecilia4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Lumley, Thomas4 aut |
700 | 1 | a McArdle, Wendy L.4 aut |
700 | 1 | a Meibohm, Bernd4 aut |
700 | 1 | a Morris, Andrew P.4 aut |
700 | 1 | a Morrison, Alanna C.4 aut |
700 | 1 | a Musk, Bill4 aut |
700 | 1 | a North, Kari E.4 aut |
700 | 1 | a Palmer, Lyle J.4 aut |
700 | 1 | a Probst-Hensch, Nicole M.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Schulz, Holger4 aut |
700 | 1 | a Smith, Lewis J.4 aut |
700 | 1 | a Sood, Akshay4 aut |
700 | 1 | a Starr, John M.4 aut |
700 | 1 | a Strachan, David P.4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Voorman, Arend4 aut |
700 | 1 | a Wain, Louise V.4 aut |
700 | 1 | a Wells, Martin T.4 aut |
700 | 1 | a Wilk, Jemma B.4 aut |
700 | 1 | a Williams, O. Dale4 aut |
700 | 1 | a Heckbert, Susan R.4 aut |
700 | 1 | a Stricker, Bruno H.4 aut |
700 | 1 | a London, Stephanie J.4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a O'Connor, George T.4 aut |
700 | 1 | a Hall, Ian P.4 aut |
700 | 1 | a Cassano, Patricia A.4 aut |
710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 9:7, s. e100776-q 9:7<e100776-x 1932-6203 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:744196/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100776&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231328 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0100776 |
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