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[11C]Acetate positr...
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Schumacher, Martin C
(författare)
[11C]Acetate positron emission tomography-computed tomography imaging of prostate cancer lymph-node metastases correlated with histopathological findings after extended lymphadenectomy
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2014-07-08
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Medical Journals Sweden AB,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-231435
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231435URI
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https://doi.org/10.3109/21681805.2014.932840DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130451968URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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ObjectiveThe aim of this study was to determine the efficacy of combined [11C]acetate positron emission tomography and computed tomography ([11C]acetate-PET/CT) in regional lymph-node staging in patients with prostate cancer (PCa).Material and methods[11C]Acetate-PET/CT was performed in 19 PCa patients who subsequently underwent extended pelvic lymph-node dissection (ePLND). The [11C]acetate-PET/CT results were compared with the surgical and histopathological findings from 13 defined lymph-node regions.Results[11C]Acetate-PET/CT was true-positive for lymph-node metastases in nine patients, false-positive in three, false-negative in one patient and true-negative in six. The patient-by-patient-based sensitivity was 90% and the specificity 67%, the positive predictive value (PPV) was 75% and the negative predictive value (NPV) 86%. From a total of 114 nodal regions (mean 5.9 regions per patient), 484 lymph nodes (mean 25.5 nodes per patient) were removed and evaluated histopathologically. Forty-six lymph nodes from 24 out of 114 (21%) nodal regions were positive for PCa metastasis. The nodal-region-based sensitivity of [11C]acetate-PET/CT was 62%, specificity was 89%, PPV 62% and NPV 89%.Conclusion[11C]Acetate-PET/CT detects PCa lymph-node metastases with high patient-by-patient-based sensitivity but low specificity, and low nodal-region-based sensitivity but high specificity. Its limited ability to detect microscopic lymph-node involvement makes ePLND essential in all patients diagnosed with positive nodes on [11C]acetate-PET/CT.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Radecka, Eva
(författare)
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Hellström, MagnusKarolinska Institutet
(författare)
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Jacobsson, Hans
(författare)
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Sundin, AndersUppsala universitet,Enheten för radiologi,Department of Radiology, Molecular Medicine & Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm , Sweden(Swepub:uu)anderssu
(författare)
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Karolinska InstitutetEnheten för radiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian journal of urology: Medical Journals Sweden AB49:1, s. 35-422168-18052168-1813
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