Sökning: onr:"swepub:oai:DiVA.org:uu-238292" >
A high birth weight...
A high birth weight is associated with increased risk of type 2 diabetes and obesity
-
- Johnsson, Inger W, 1973- (författare)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
-
- Haglund, Bengt (författare)
- Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH)
-
- Ahlsson, Fredrik, 1967- (författare)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
-
visa fler...
-
- Gustafsson, Jan, 1948- (författare)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
-
visa färre...
-
(creator_code:org_t)
- 2014-06-11
- 2015
- Engelska.
-
Ingår i: Pediatric Obesity. - : Wiley. - 2047-6302 .- 2047-6310. ; 10:2, s. 77-83
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: The association between low birth weight and adult disease is well known. Less is known on long-term effects of high birth weight.OBJECTIVE: This study aims to investigate whether a high birth weight increases risk for adult metabolic disease.METHODS: Swedish term single births, 1973-1982 (n = 759 999), were studied to age 27.5-37.5 years using Swedish national registers. Hazard ratios (HRs) were calculated in relation to birth weight for type 2 diabetes, obesity, hypertension and dyslipidaemia.RESULTS: Men with birth weights between 2 and 3 standard deviation score (SDS) had a 1.9-fold increased risk (HR 1.91, 95% confidence interval [CI] 1.25-2.90) of type 2 diabetes, whereas those with birth weights above 3 SDS had a 5.4-fold increased risk (HR 5.44, 95% CI 2.70-10.96) compared to men with birth weights between -2 and 2 SDS. The corresponding HRs for women were 0.60 (95% CI 0.40-0.91) and 1.71 (95% CI 0.85-3.43) for birth weights 2-3 SDS and >3 SDS, respectively. Men with birth weights between 2 and 3 SDS had a 1.5-fold increased risk (HR 1.47, 95% CI 1.22-1.77) of obesity. The corresponding risk for women was 1.3-fold increased (HR 1.32, 95% CI 1.19-1.46). For men and women with birth weights above 3 SDS, the risks of adult obesity were higher, HR 2.46 (95% CI 1.63-3.71) and HR 1.85 (95% CI 1.44-2.37), respectively.CONCLUSIONS: A high birth weight, particularly very high, increases the risk of type 2 diabetes in male young adults. The risk of obesity increases with increasing birth weight in both genders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas