New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs.

Ackley, Brian (author)
Araç, Demet (author)
Ariestanti, Donna M (author)
Aust, Gabriela (author)
Bae, Byoung-Il (author)
Bista, Bigyan R (author)
Bridges, James P (author)
Duman, Joseph G (author)
Engel, Felix B (author)
Giera, Stefanie (author)
Goffinet, André M (author)
Hall, Randy A (author)
Hamann, Jörg (author)
Hartmann, Nicole (author)
Lin, Hsi-Hsien (author)
Liu, Mingyao (author)
Luo, Rong (author)
Mogha, Amit (author)
Monk, Kelly R (author)
Peeters, Miriam C (author)
Prömel, Simone (author)
Ressl, Susanne (author)
Schiöth, Helgi BUppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi (author)
Sigoillot, Séverine M (author)
Song, Helen (author)
Talbot, William S (author)
Tall, Gregory G (author)
White, James P (author)
Wolfrum, Uwe (author)
Xu, Lei (author)
Piao, Xianhua (author)
Uppsala universitetFunktionell farmakologi (creator_code:org_t)

In:Annals of the New York Academy of Sciences: Wiley1333, s. 43-640077-89231749-6632

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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