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Increased hippocamp...
Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity
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- Nordenankar, Karin (författare)
- Uppsala universitet,Funktionell farmakologi,Genetisk utvecklingsbiologi
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- Smith-Anttila, Casey J A (författare)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Schweizer, Nadine (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Viereckel, Thomas (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Birgner, Carolina (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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Mejia-Toiber, Jana (författare)
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Morales, Marisela (författare)
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- Leao, Richardson Naves (författare)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Wallén-Mackenzie, Åsa (författare)
- Uppsala universitet,Genetisk utvecklingsbiologi
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(creator_code:org_t)
- 2014-05-07
- 2015
- Engelska.
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Ingår i: Brain Structure and Function. - : Springer Science and Business Media LLC. - 1863-2653 .- 1863-2661. ; 220:4, s. 2171-2190
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these populations ("TH-Vglut2 Class1") also expressed the dopamine transporter (DAT) gene while one did not ("TH-Vglut2 Class2"), and the remaining population did not express TH at all ("Vglut2-only"). TH is known to be expressed by a promoter which shows two phases of activation, a transient one early during embryonal development, and a later one which gives rise to stable endogenous expression of the TH gene. The transient phase is, however, not specific to catecholaminergic neurons, a feature taken to advantage here as it enabled Vglut2 gene targeting within all three A10 populations expressing this gene, thus creating a new conditional knockout. These knockout mice showed impairment in spatial memory function. Electrophysiological analyses revealed a profound alteration of oscillatory activity in the CA3 region of the hippocampus. In addition to identifying a novel role for Vglut2 in hippocampus function, this study points to the need for improved genetic tools for targeting of the diversity of subpopulations of the A10 area.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (ämneskategori)
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