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Genomic identificat...
Genomic identification and characterization of the pseudoautosomal region in highly differentiated avian sex chromosomes
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- Smeds, Linnea (författare)
- Uppsala universitet,Evolutionsbiologi
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- Kawakami, Takeshi (författare)
- Uppsala universitet,Evolutionsbiologi
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- Burri, Reto (författare)
- Uppsala universitet,Evolutionsbiologi
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- Bolivar, Paulina (författare)
- Uppsala universitet,Evolutionsbiologi
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Husby, Arild (författare)
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- Qvarnström, Anna (författare)
- Uppsala universitet,Zooekologi
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- Uebbing, Severin (författare)
- Uppsala universitet,Evolutionsbiologi
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- Ellegren, Hans (författare)
- Uppsala universitet,Evolutionsbiologi
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(creator_code:org_t)
- 2014-11-07
- 2014
- Engelska.
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 5448-
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be identified. Here we use linkage analysis together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological model species, the collared flycatcher. The PAR contains 22 protein-coding genes and is GC rich. The genetic length is 64cM in female meiosis, consistent with an obligate crossing-over event. Recombination is concentrated to a hotspot region, with an extreme rate of > 700 cM/Mb in a 67-kb segment. We find no signatures of sexual antagonism and propose that sexual antagonism may have limited influence on PAR sequences when sex chromosomes are nearly fully differentiated and when a recombination hotspot region is located close to the PAR boundary. Our results demonstrate that a very small PAR suffices to ensure homologous recombination and proper segregation of sex chromosomes during meiosis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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