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Sökning: onr:"swepub:oai:DiVA.org:uu-244517" > Immune response and...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03492naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-244517 | |
| 003 | SwePub | |
| 008 | 150217s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2445172 URI |
| 024 | 7 | a https://doi.org/10.1016/j.vetimm.2014.10.0042 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Camussone, C. M.4 aut |
| 245 | 1 0 | a Immune response and functional role of antibodies raised in heifers against a Staphylococcus aureus CP5 lysate and recombinant antigens vaccine formulated with Iscom Matrix adjuvant |
| 264 | 1 | b Elsevier BV,c 2014 |
| 338 | a print2 rdacarrier | |
| 520 | a Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary infections worldwide. Commercially available vaccines for mastitis control are composed either of S. aureus lysates or inactivated whole-cells formulated with traditional adjuvants. We recently showed the ability of a S. aureus CP5 lysate vaccine adjuvanted with Iscom Matrix to generate a longer lasting specific antibody response in blood and milk with improved opsonic capacity compared with a S. aureus CP5 whole-cell formulation. The aim of the present study was to obtain an experimental immunogen composed of lysed cells of a CP5 S. aureus strain supplemented with recombinant clumping factor A fibronectin binding protein A and beta-toxin formulated with Iscom Matrix characterize the immune response generated when immunizing pregnant heifers and assess the functional role of antibodies raised against this immunogen in experimental models. Both a lysate vaccine and a lysate + recombinant antigens vaccine elicited antibodies that promoted neutrophil phagocytosis and inhibited internalization into mammary epithelial cells in vitro. Incorporation of defined antigenic molecules to the lysate formulation elicited a strong specific humoral immune response against both lysate and recombinant antigens and was associated with higher expression of regulatory and pro-inflammatory cytokines. In addition antibodies were efficient for blocking S. aureus binding to bovine fibrinogen and fibronectin and neutralizing beta-toxin effect in vitro placing these antigens as candidates to be included in a formulation directed to prevent staphylococcal bovine mastitis. (C) 2014 Elsevier B.V. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Staphylococcus aureus | |
| 653 | a Bovine mastitis | |
| 653 | a Immunization | |
| 653 | a Lysate | |
| 653 | a Recombinant antigens | |
| 653 | a Iscom Matrix | |
| 700 | 1 | a Pujato, N.4 aut |
| 700 | 1 | a Renna, M. S.4 aut |
| 700 | 1 | a Veaute, C. M.4 aut |
| 700 | 1 | a Morein, Broru Uppsala universitet,Klinisk virologi4 aut |
| 700 | 1 | a Marcipar, I. S.4 aut |
| 700 | 1 | a Calvinho, L. F.4 aut |
| 710 | 2 | a Uppsala universitetb Klinisk virologi4 org |
| 773 | 0 | t Veterinary Immunology and Immunopathologyd : Elsevier BVg 162:3-4, s. 96-107q 162:3-4<96-107x 0165-2427x 1873-2534 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244517 |
| 856 | 4 8 | u https://doi.org/10.1016/j.vetimm.2014.10.004 |
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