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Does menopausal hor...
Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? : A population-based case-control study
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- Carrasquilla, Germán D (författare)
- Karolinska Institutet
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- Berglund, Anita (författare)
- Karolinska Institutet
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- Gigante, Bruna (författare)
- Karolinska Institutet
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Landgren, Britt-Marie (författare)
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- de Faire, Ulf (författare)
- Karolinska Institutet
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- Hallqvist, Johan (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Leander, Karin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: Menopause. - 1072-3714 .- 1530-0374. ; 22:6, s. 598-606
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk.METHODS: This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression.RESULTS: Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48).CONCLUSIONS: Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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