Sökning: onr:"swepub:oai:DiVA.org:uu-245321" > Polymorphisms in Pl...
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000 | 05676naa a2201033 4500 | |
001 | oai:DiVA.org:uu-245321 | |
003 | SwePub | |
008 | 150226s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129864897 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2453212 URI |
024 | 7 | a https://doi.org/10.4269/ajtmh.14-00312 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1298648972 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Venkatesan, Meera4 aut |
245 | 1 0 | a Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes :b parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. |
264 | 1 | b American Society of Tropical Medicine and Hygiene,c 2014 |
338 | a print2 rdacarrier | |
520 | a Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29 - 9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001 : were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine. | |
700 | 1 | a Gadalla, Nahla B4 aut |
700 | 1 | a Stepniewska, Kasia4 aut |
700 | 1 | a Dahal, Prabin4 aut |
700 | 1 | a Nsanzabana, Christian4 aut |
700 | 1 | a Moriera, Clarissa4 aut |
700 | 1 | a Price, Ric N4 aut |
700 | 1 | a Mårtensson, Andreasu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)andma331 |
700 | 1 | a Rosenthal, Philip J4 aut |
700 | 1 | a Dorsey, Grant4 aut |
700 | 1 | a Sutherland, Colin J4 aut |
700 | 1 | a Guérin, Philippe4 aut |
700 | 1 | a Davis, Timothy M E4 aut |
700 | 1 | a Ménard, Didier4 aut |
700 | 1 | a Adam, Ishag4 aut |
700 | 1 | a Ademowo, George4 aut |
700 | 1 | a Arze, Cesar4 aut |
700 | 1 | a Baliraine, Frederick N4 aut |
700 | 1 | a Berens-Riha, Nicole4 aut |
700 | 1 | a Björkman, Andersu Karolinska Institutet4 aut |
700 | 1 | a Borrmann, Steffen4 aut |
700 | 1 | a Checchi, Francesco4 aut |
700 | 1 | a Desai, Meghna4 aut |
700 | 1 | a Dhorda, Mehul4 aut |
700 | 1 | a Djimdé, Abdoulaye A4 aut |
700 | 1 | a El-Sayed, Badria B4 aut |
700 | 1 | a Eshetu, Teferi4 aut |
700 | 1 | a Eyase, Frederick4 aut |
700 | 1 | a Falade, Catherine4 aut |
700 | 1 | a Faucher, Jean-François4 aut |
700 | 1 | a Fröberg, Gabrielleu Karolinska Institutet4 aut |
700 | 1 | a Grivoyannis, Anastasia4 aut |
700 | 1 | a Hamour, Sally4 aut |
700 | 1 | a Houzé, Sandrine4 aut |
700 | 1 | a Johnson, Jacobu Karolinska Institutet4 aut |
700 | 1 | a Kamugisha, Erasmus4 aut |
700 | 1 | a Kariuki, Simon4 aut |
700 | 1 | a Kiechel, Jean-René4 aut |
700 | 1 | a Kironde, Fred4 aut |
700 | 1 | a Kofoed, Poul-Erik4 aut |
700 | 1 | a LeBras, Jacques4 aut |
700 | 1 | a Malmberg, Maja4 aut |
700 | 1 | a Mwai, Leah4 aut |
700 | 1 | a Ngasala, Billy4 aut |
700 | 1 | a Nosten, Francois4 aut |
700 | 1 | a Nsobya, Samuel L4 aut |
700 | 1 | a Nzila, Alexis4 aut |
700 | 1 | a Oguike, Mary4 aut |
700 | 1 | a Otienoburu, Sabina Dahlström4 aut |
700 | 1 | a Ogutu, Bernhards4 aut |
700 | 1 | a Ouédraogo, Jean-Bosco4 aut |
700 | 1 | a Piola, Patrice4 aut |
700 | 1 | a Rombo, Larsu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)larra728 |
700 | 1 | a Schramm, Birgit4 aut |
700 | 1 | a Somé, A Fabrice4 aut |
700 | 1 | a Thwing, Julie4 aut |
700 | 1 | a Ursing, Johan4 aut |
700 | 1 | a Wong, Rina P M4 aut |
700 | 1 | a Zeynudin, Ahmed4 aut |
700 | 1 | a Zongo, Issaka4 aut |
700 | 1 | a Plowe, Christopher V4 aut |
700 | 1 | a Sibley, Carol Hopkins4 aut |
710 | 2 | a Uppsala universitetb Centrum för klinisk forskning i Sörmland (CKFD)4 org |
773 | 0 | t The American journal of tropical medicine and hygiened : American Society of Tropical Medicine and Hygieneg 91:4, s. 833-43q 91:4<833-43x 1476-1645x 0002-9637 |
856 | 4 | u https://europepmc.org/articles/pmc4183414?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-245321 |
856 | 4 8 | u https://doi.org/10.4269/ajtmh.14-0031 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129864897 |
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