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N-Methyl-D-Aspartat...
N-Methyl-D-Aspartate Receptor Autoimmunity Affects Cognitive Performance in Herpes Simplex Encephalitis
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- Westman, Gabriel (författare)
- Uppsala University,Uppsala universitet,Infektionssjukdomar
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- Studahl, Marie, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Persson, Barbro (författare)
- Uppsala University,Uppsala universitet,Klinisk immunologi
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- Ahlm, Clas (författare)
- Umeå universitet,Umeå University,Infektionssjukdomar,Umea Univ, Dept Clin Microbiol, Infect Dis, Umea, Sweden
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- Eriksson, Britt-Marie (författare)
- Uppsala University,Uppsala universitet,Infektionssjukdomar
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- Rönnelid, Johan (författare)
- Uppsala University,Uppsala universitet,Klinisk immunologi
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- Schliamser, S. (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Lund University, Lund, Sweden
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- Aurelius, Elisabeth (författare)
- Karolinska Institutet,Karolinska Institute,Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Sweden
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Clinical Microbiology And Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 22:11, s. 934-940
- Relaterad länk:
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http://www.clinicalm...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: To investigate the prevalence and temporal development of N-methyl-D-aspartate receptor (NMDAR) autoantibodies in relation to neurocognitive performance in patients with herpes simplex encephalitis (HSE). Methods: This prospective observational study enrolled a total of 49 HSE patients within a randomized controlled trial of valacyclovir. Cerebrospinal fluid and serum samples were drawn in the initial stage of disease, after 2 to 3 weeks and after 3 months. Anti-NMDAR IgG was detected with HEK293 cells transfected with plasmids encoding the NMDA NR1 type glutamate receptor. A batch of neurocognitive tests, including the Mattis Dementia Rating Scale (MDRS), Glasgow Coma Scale (GCS), Reaction Level Scale (RLS85), Mini-Mental State Examination (MMSE) and National Institutes of Health (NIH) stroke scale, was performed during 24 months' follow-up. Results: Anti-NMDAR IgG was detected in 12 of 49 participants. None were antibody positive in the initial stage of disease. In ten of 12 positive cases, specific antibodies were detectable only after 3 months. Notably, the development of NMDAR autoantibodies was associated with significantly impaired recovery of neurocognitive performance. After 24 months' follow-up, the median increase in MDRS total score was 1.5 vs. 10 points in antibody-positive and -negative participants (p = 0.018). Conclusions: Anti-NMDAR autoimmunity is a common complication to HSE that develops within 3 months after onset of disease. The association to impaired neurocognitive recovery could have therapeutical implications, as central nervous system autoimmunity is potentially responsive to immunotherapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Autoantibodies
- Autoimmunity
- Herpes simplex encephalitis
- IgG
- Mattis Dementia Rating Scale
- N-methyl-D-aspartate receptor
- Neurocognitive impairment
- NMDAR
- Medicinsk vetenskap
- Medical Science
- Autoantibodies
- Autoimmunity
- Herpes simplex encephalitis
- IgG
- Mattis Dementia Rating Scale
- N-methyl-d-aspartate receptor
- Neurocognitive impairment
- NMDAR
- N-methyl-asparate receptor antibodies
- herpes simplex encephalitis
- cognition
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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