Sökning: onr:"swepub:oai:DiVA.org:uu-24875" >
Identification and ...
Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines
-
- Larsson, Dhana E. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
- Lövborg, Henrik (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics
-
- Rickardson, Linda (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics
-
visa fler...
-
- Larsson, Rolf (författare)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics
-
- Öberg, Kjell (författare)
- Uppsala universitet,Medicin
-
- Granberg, Dan (författare)
- Karolinska Institutet,Uppsala universitet,Medicin
-
visa färre...
-
(creator_code:org_t)
- 2006
- 2006
- Engelska.
-
Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 26:6B, s. 4125-4129
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. Materials and Methods: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. Results: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC50 values < 1 μM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bay11-7085, mitoxantrone, doxorubicin, β-lapachone, NSC 95397 and CGP-74514A. Conclusion: The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
Nyckelord
- Drug sensitivity
- FMCA
- Neuroendocrine tumors
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas