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Identification and ...
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Larsson, Dhana E.Uppsala universitet,Institutionen för medicinska vetenskaper
(författare)
Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines
- Artikel/kapitelEngelska2006
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LIBRIS-ID:oai:DiVA.org:uu-24875
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-24875URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:112546561URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. Materials and Methods: In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. Results: The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC50 values < 1 μM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bay11-7085, mitoxantrone, doxorubicin, β-lapachone, NSC 95397 and CGP-74514A. Conclusion: The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
Ämnesord och genrebeteckningar
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Drug sensitivity
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FMCA
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Neuroendocrine tumors
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lövborg, HenrikUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics
(författare)
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Rickardson, LindaUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics(Swepub:uu)liric020
(författare)
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Larsson, RolfUppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics(Swepub:uu)rolflars
(författare)
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Öberg, KjellUppsala universitet,Medicin(Swepub:uu)kjellob
(författare)
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Granberg, DanKarolinska Institutet,Uppsala universitet,Medicin(Swepub:uu)dangb
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Anticancer Research26:6B, s. 4125-41290250-70051791-7530
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