onr:"swepub:oai:DiVA.org:uu-254385"
Sökning: onr:"swepub:oai:DiVA.org:uu-254385" > Adverse effects of ...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Gedeborg, RolfUppsala universitet,Anestesiologi och intensivvård (författare)
Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
- 2000
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-254385
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254385URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- OBJECTIVE:To study the effects of high-dose epinephrine, compared with standard-dose epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global cerebral oxygenation during experimental cardiopulmonary resuscitation. We hypothesized that high-dose epinephrine might be unable to improve cerebral blood flow during cardiopulmonary resuscitation as compared with standard-dose epinephrine.DESIGN:Randomized controlled study.SETTING:University hospital research laboratory.SUBJECTS:A total of 20 male anesthetized piglets.INTERVENTIONS:Ventricular fibrillation was induced. A nonintervention interval of 8 mins was followed by open-chest cardiopulmonary resuscitation. The animals were randomized to receive repeated bolus injections of either 20 microg/kg (standard-dose group, n = 10) or 200 microg/kg (high-dose group, n = 10) of epinephrine.MEASUREMENTS AND MAIN RESULTS:Focal cortical cerebral blood flow was measured continuously by using laser Doppler flowmetry. The duration of blood flow increase was significantly shorter in the high-dose group after the second dose of epinephrine. In the high-dose group there was also a consistent tendency for lower peak levels and shorter duration of flow increase in response to repeated bolus doses of epinephrine. Cerebral oxygen extraction ratio was significantly lower in the high-dose group after administration of epinephrine.CONCLUSIONS:Repeated bolus doses of epinephrine 200 microg/kg, as compared with 20 microg/kg, do not improve superficial cortical cerebral blood flow during experimental open-chest cardiopulmonary resuscitation. High-dose epinephrine appears to induce vasoconstriction of cortical cerebral blood vessels resulting in redistribution of blood flow from superficial cortex. This might be one explanation for the failure of high-dose epinephrine to improve overall outcome in clinical trials.
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Silander, H C (författare)
- Ronne-Engström, ElisabethUppsala universitet,Neurokirurgi(Swepub:uu)elisronn (författare)
- Rubertsson, StenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)stenrube (författare)
- Wiklund, LarsUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)larswikl (författare)
- Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Critical Care Medicine28:5, s. 1423-14300090-34931530-0293
Internetlänk
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Gedeborg, Rolf
- Silander, H C
- Ronne-Engström, ...
- Rubertsson, Sten
- Wiklund, Lars
- Artiklar i publikationen
- Critical Care Me ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
