Sökning: onr:"swepub:oai:DiVA.org:uu-255057" > Pyrylium Salts as R...
Fältnamn | Indikatorer | Metadata |
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000 | 03336naa a2200505 4500 | |
001 | oai:DiVA.org:uu-255057 | |
003 | SwePub | |
008 | 150612s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131235682 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2550572 URI |
024 | 7 | a https://doi.org/10.1007/s13361-015-1119-92 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1312356822 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shariatgorji, Mohammadreza4 aut |
245 | 1 0 | a Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines |
264 | c 2015-03-28 | |
264 | 1 | b American Chemical Society (ACS),c 2015 |
338 | a print2 rdacarrier | |
520 | a Many neuroactive substances, including endogenous biomolecules, environmental compounds, and pharmaceuticals possess primary amine functional groups. Among these are catecholamine neurotransmitters (e.g., dopamine), many substituted phenethylamines (e.g., amphetamine), as well as amino acids and neuropeptides. In most cases, mass spectrometric (ESI and MALDI) analyses of trace amounts of such compounds are challenging because of their poor ionization properties. We present a method for chemical derivatization of primary amines by reaction with pyrylium salts that facilitates their detection by MALDI-MS and enables the imaging of primary amines in brain tissue sections. A screen of pyrylium salts revealed that the 2,4-diphenyl-pyranylium ion efficiently derivatizes primary amines and can be used as a reactive MALDI-MS matrix that induces both derivatization and desorption. MALDI-MS imaging with such matrix was used to map the localization of dopamine and amphetamine in brain tissue sections and to quantitatively map the distribution of the neurotoxin beta-N-methylamino-L-alanine. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
653 | a MALDI matrix | |
653 | a Mass spectrometry imaging | |
653 | a Neurotransmitter | |
653 | a Catecholamine | |
653 | a Phenethylamine | |
653 | a Amphetamine | |
653 | a Primary amine | |
653 | a Reactive matrix | |
653 | a Neurotoxin | |
700 | 1 | a Nilsson, Anna4 aut |
700 | 1 | a Kallback, Patrik4 aut |
700 | 1 | a Karlsson, Oskaru Karolinska Institutet,Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)oskar255 |
700 | 1 | a Zhang, Xiaoqunu Karolinska Institutet4 aut |
700 | 1 | a Svenningsson, Peru Karolinska Institutet4 aut |
700 | 1 | a Andren, Per E.4 aut |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t Journal of the American Society for Mass Spectrometryd : American Chemical Society (ACS)g 26:6, s. 934-939q 26:6<934-939x 1044-0305x 1879-1123 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255057 |
856 | 4 8 | u https://doi.org/10.1007/s13361-015-1119-9 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131235682 |
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