onr:"swepub:oai:DiVA.org:uu-256145"
Sökning: onr:"swepub:oai:DiVA.org:uu-256145" > Expression of the A...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03108naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-256145 | |
| 003 | SwePub | |
| 008 | 150622s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:131264971 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2561452 URI |
| 024 | 7 | a https://doi.org/10.3390/ijms160480592 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1312649712 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cedervall, Thereseu Karolinska Institutet4 aut |
| 245 | 1 0 | a Expression of the Aryl Hydrocarbon Receptor in Growth Plate Cartilage and the Impact of Its Local Modulation on Longitudinal Bone Growth |
| 264 | c 2015-04-10 | |
| 264 | 1 | b MDPI AG,c 2015 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Although dioxin has been reported to impair bone growth in both humans and animals, the underlying mechanisms have not been clarified. We conducted this study to rule out if dioxin may directly target the growth plate, via local modulation of the aryl hydrocarbon receptor (AhR). Initial studies in rare tissue samples of the human growth plate confirmed that the AhR protein is widely expressed in growth plate cartilage. To explore the local role of the AhR, mechanistic studies were performed in a well-established model of cultured fetal rat metatarsal bones. The longitudinal growth of these bones was monitored while being exposed to AhR modulators. The AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin, did not affect bone growth at any concentrations tested (1 pM-10 nM). In contrast, the AhR antagonist, alpha-naphthoflavone, suppressed bone growth and increased chondrocyte apoptosis, although only at a high, potentially cytotoxic concentration (50 mu M). We conclude that although the AhR is widely expressed in the growth plate, bone growth is not modulated when locally activated, and therefore, dioxin-induced growth failure is likely mediated through systemic rather than local actions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
| 700 | 1 | a Lind, P. Monicau Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)monilind |
| 700 | 1 | a Savendahl, Larsu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Arbets- och miljömedicin4 org |
| 773 | 0 | t International Journal of Molecular Sciencesd : MDPI AGg 16:4, s. 8059-8069q 16:4<8059-8069x 1661-6596x 1422-0067 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:824702/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.mdpi.com/1422-0067/16/4/8059/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256145 |
| 856 | 4 8 | u https://doi.org/10.3390/ijms16048059 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131264971 |
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