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Glioma-derived plas...
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
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- Roy, Ananya (författare)
- Uppsala universitet,Neuroonkologi
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Coum, Antoine (författare)
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- Marinescu, Voichita D (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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Põlajeva, Jelena (författare)
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- Smits, Anja (författare)
- Uppsala universitet,Neurologi,Neurology
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- Nelander, Sven (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Uhrbom, Lene (författare)
- Uppsala universitet,Neuroonkologi
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- Westermark, Bengt (författare)
- Uppsala universitet,Neuroonkologi
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- Forsberg-Nilsson, Karin (författare)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Pontén, Fredrik (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Tchougounova, Elena (författare)
- Uppsala universitet,Neuroonkologi
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(creator_code:org_t)
- 2015-06-25
- 2015
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:27, s. 23647-23661
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glioblastoma (GBM) is a high-grade glioma with a complex microenvironment, including various inflammatory cells and mast cells (MCs) as one of them. Previously we had identified glioma grade-dependent MC recruitment. In the present study we investigated the role of plasminogen activator inhibitor 1 (PAI-1) in MC recruitment.PAI-1, a primary regulator in the fibrinolytic cascade is capable of forming a complex with fibrinolytic system proteins together with low-density lipoprotein receptor-related protein 1 (LRP1). We found that neutralizing PAI-1 attenuated infiltration of MCs. To address the potential implication of LRP1 in this process, we used a LRP1 antagonist, receptor-associated protein (RAP), and demonstrated the attenuation of MC migration. Moreover, a positive correlation between the number of MCs and the level of PAI-1 in a large cohort of human glioma samples was observed. Our study demonstrated the expression of LRP1 in human MC line LAD2 and in MCs in human high-grade glioma. The activation of potential PAI-1/LRP1 axis with purified PAI-1 promoted increased phosphorylation of STAT3 and subsequently exocytosis in MCs.These findings indicate the influence of the PAI-1/LRP1 axis on the recruitment of MCs in glioma. The connection between high-grade glioma and MC infiltration could contribute to patient tailored therapy and improve patient stratification in future therapeutic trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- mast cell
- glioma
- PAI-1
- SERPINE1
- LRP1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Roy, Ananya
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Coum, Antoine
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Marinescu, Voich ...
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Põlajeva, Jelena
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Smits, Anja
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Nelander, Sven
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visa fler...
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Uhrbom, Lene
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Westermark, Beng ...
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Forsberg-Nilsson ...
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Pontén, Fredrik
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Tchougounova, El ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Oncotarget
- Av lärosätet
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Uppsala universitet