Sökning: onr:"swepub:oai:DiVA.org:uu-261927" > Alterations of the ...
Fältnamn | Indikatorer | Metadata |
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000 | 03265naa a2200445 4500 | |
001 | oai:DiVA.org:uu-261927 | |
003 | SwePub | |
008 | 150907s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2619272 URI |
024 | 7 | a https://doi.org/10.1002/gcc.222762 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Schneider, Markus4 aut |
245 | 1 0 | a Alterations of the CD58 gene in classical Hodgkin lymphoma |
264 | c 2015-07-21 | |
264 | 1 | b Wiley,c 2015 |
338 | a print2 rdacarrier | |
520 | a Immune evasion plays a central role in the pathophysiology of classical Hodgkin lymphoma (cHL). As mutations of the CD58 gene contribute to immune evasion of diffuse large B cell lymphoma tumor cells, we studied whether alterations of the CD58 gene also occur in Hodgkin and Reed/Sternberg (HRS) cells of cHL. Single nucleotide polymorphism chip analysis revealed homozygous deletions within the CD58 gene in two cHL cell lines (SUP-HD1 and U-HO1). Sequencing of the CD58 gene in seven cHL cell lines disclosed in addition a homozygous splice site mutation in cell line KM-H2. None of the three mutated lines expressed CD58 protein on their surface. Thus, three of seven cHL cell lines analyzed harbor destructive CD58 mutations. Molecular analysis of isolated HRS cells from 10 primary cases of cHL; however, did not reveal any case with a CD58 mutation. A FICTION study indicated heterozygous deletions of CD58 in 3 of 13 cHL analyzed. Overall, we report frequent inactivating mutations of CD58 in cHL cell lines, but their rare occurrence in primary HRS cells. As the three cHL cell lines with CD58 mutations were all established from HRS cells located in pleural effusions, i.e., outside the normal lymph node microenvironment, in end-stages of the disease, CD58 inactivation in cHL might be predominantly prevalent to such situations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Schneider, Stefanie4 aut |
700 | 1 | a Zuehlke-Jenisch, Reina4 aut |
700 | 1 | a Klapper, Wolfram4 aut |
700 | 1 | a Sundström, Christeru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)chrisund |
700 | 1 | a Hartmann, Sylvia4 aut |
700 | 1 | a Hansmann, Martin-Leo4 aut |
700 | 1 | a Siebert, Reiner4 aut |
700 | 1 | a Kueppers, Ralf4 aut |
700 | 1 | a Giefing, Maciej4 aut |
710 | 2 | a Uppsala universitetb Klinisk och experimentell patologi4 org |
773 | 0 | t Genes, Chromosomes and Cancerd : Wileyg 54:10, s. 638-645q 54:10<638-645x 1045-2257x 1098-2264 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261927 |
856 | 4 8 | u https://doi.org/10.1002/gcc.22276 |
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