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Increased Number of...
Increased Number of Plasma B Cells Producing Autoantibodies Against A beta(42) Protofibrils in Alzheimer's Disease
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- Söllvander, Sofia (författare)
- Uppsala universitet,Geriatrik
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- Ekholm-Pettersson, Frida (författare)
- Uppsala universitet,Geriatrik
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- Brundin, Rose-Marie (författare)
- Uppsala universitet,Geriatrik
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- Westman, Gabriel (författare)
- Uppsala universitet,Infektionssjukdomar
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- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
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- Paulie, Staffan (författare)
- Mabtech AB, Nacka Strand, Sweden.
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- Lannfelt, Lars (författare)
- Uppsala universitet,Geriatrik
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- Sehlin, Dag (författare)
- Uppsala universitet,Geriatrik,Uppsala Univ, Rudbeck Lab, Dept Publ Hlth & Caring Sci Mol Geriatr, S-75185 Uppsala, Sweden.
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 48:1, s. 63-72
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The Alzheimer's disease (AD)-related peptide amyloid-beta (A beta) has a propensity to aggregate into various assemblies including toxic soluble A beta protofibrils. Several studies have reported the existence of anti-A beta antibodies in humans. However, it is still debated whether levels of anti-A beta antibodies are altered in AD patients compared to healthy individuals. Formation of immune complexes with plasma A beta makes it difficult to reliably measure the concentration of circulating anti-A beta antibodies with certain immunoassays, potentially leading to an underestimation. Here we have investigated anti-A beta antibody production on a cellular level by measuring the amount of anti-A beta antibody producing cells instead of the plasma level of anti-A beta antibodies. To our knowledge, this is the first time the anti-A beta antibody response in plasma has been compared in AD patients and age-matched healthy individuals using the enzyme-linked immunospot (ELISpot) technique. Both AD patients and healthy individuals had low levels of B cells producing antibodies binding A beta(40) monomers, whereas the number of cells producing antibodies toward A beta(42) protofibrils was higher overall and significantly higher in AD compared to healthy controls. This study shows, by an alternative and reliable method, that there is a specific immune response to the toxic A beta protofibrils, which is significantly increased in AD patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Amyloid-beta
- amyloid-beta protofibrils
- anti-amyloid-beta antibodies
- enzyme-linked immunospot assay
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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