SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-265004"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-265004" > Quantification of [...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003833naa a2200409 4500
001oai:DiVA.org:uu-265004
003SwePub
008151020s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2650042 URI
0247 a https://doi.org/10.1186/s13550-014-0052-42 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Harms, Hendrik J4 aut
2451 0a Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium
264 c 2014-09-26
264 1b Springer Science and Business Media LLC,c 2014
338 a electronic2 rdacarrier
520 a BACKGROUND: The aims of this study were to determine the optimal tracer kinetic model for [(11)C]-meta-hydroxyephedrine ([(11)C]HED) and to evaluate the performance of several simplified methods.METHODS: Thirty patients underwent dynamic 60-min [(11)C]HED scans with online arterial blood sampling. Single-tissue and both reversible and irreversible two-tissue models were fitted to the data using the metabolite-corrected arterial input function. For each model, reliable fits were defined as those yielding outcome parameters with a coefficient of variation (CoV) <25%. The optimal model was determined using Akaike and Schwarz criteria and the F-test, together with the number of reliable fits. Simulations were performed to study accuracy and precision of each model. Finally, quantitative results obtained using a population-averaged metabolite correction were evaluated, and simplified retention index (RI) and standardized uptake value (SUV) results were compared with quantitative volume of distribution (V T) data.RESULTS: The reversible two-tissue model was preferred in 75.8% of all segments, based on the Akaike information criterion. However, V T derived using the single-tissue model correlated highly with that of the two-tissue model (r (2) = 0.94, intraclass correlation coefficient (ICC) = 0.96) and showed higher precision (CoV of 24.6% and 89.2% for single- and two-tissue models, respectively, at 20% noise). In addition, the single-tissue model yielded reliable fits in 94.6% of all segments as compared with 77.1% for the reversible two-tissue model. A population-averaged metabolite correction could not be used in approximately 20% of the patients because of large biases in V T. RI and SUV can provide misleading results because of non-linear relationships with V T.CONCLUSIONS: Although the reversible two-tissue model provided the best fits, the single-tissue model was more robust and results obtained were similar. Therefore, the single-tissue model was preferred. RI showed a non-linear correlation with V T, and therefore, care has to be taken when using RI as a quantitative measure.
7001 a de Haan, Stefan4 aut
7001 a Knaapen, Paul4 aut
7001 a Allaart, Cornelis P4 aut
7001 a Rijnierse, Mischa T4 aut
7001 a Schuit, Robert C4 aut
7001 a Windhorst, Albert D4 aut
7001 a Lammertsma, Adriaan A4 aut
7001 a Huisman, Marc C4 aut
7001 a Lubberink, Marku Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)marklubb
7102 a Uppsala universitetb Enheten för nuklearmedicin och PET4 org
7730 t EJNMMI Researchd : Springer Science and Business Media LLCg 4q 4x 2191-219X
8564 u https://doi.org/10.1186/s13550-014-0052-4y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:862194/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-014-0052-4
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265004
8564 8u https://doi.org/10.1186/s13550-014-0052-4

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy