Sökning: onr:"swepub:oai:DiVA.org:uu-265697" > In Vivo Effects of ...
Fältnamn | Indikatorer | Metadata |
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000 | 06937naa a2200769 4500 | |
001 | oai:DiVA.org:uu-265697 | |
003 | SwePub | |
008 | 151102s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:132122757 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2656972 URI |
024 | 7 | a https://doi.org/10.5966/sctm.2015-00212 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1321227572 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Simonson, Oscar E.u Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.4 aut |
245 | 1 0 | a In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome |
264 | c 2015-08-18 | |
264 | 1 | b Oxford University Press (OUP),c 2015 |
338 | a print2 rdacarrier | |
500 | a De 2 första författarna delar förstaförfattarskapet.De 3 sista författarna delar sistaförfattarskapet. | |
520 | a Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213 | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
653 | a Acute respiratory distress syndrome | |
653 | a Pulmonary diseases | |
653 | a Respiratory tract | |
653 | a Stem cells | |
653 | a Cell transplantation | |
653 | a Bone marrow stromal cells | |
653 | a Cellular therapy | |
653 | a Clinical translation | |
700 | 1 | a Mougiakakos, Dimitriosu Univ Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany.4 aut |
700 | 1 | a Heldring, Ninau Karolinska Institutet4 aut |
700 | 1 | a Bassi, Giuliou Univ Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy.4 aut |
700 | 1 | a Johansson, Henrik J.u Karolinska Institutet4 aut |
700 | 1 | a Dalen, Magnusu Karolinska Institutet4 aut |
700 | 1 | a Jitschin, Reginau Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.4 aut |
700 | 1 | a Rodin, Sergeyu Karolinska Institutet4 aut |
700 | 1 | a Corbascio, Matthiasu Karolinska Institutet4 aut |
700 | 1 | a El Andaloussi, Samiru Karolinska Institutet4 aut |
700 | 1 | a Wiklander, Oscar P. B.u Karolinska Institutet4 aut |
700 | 1 | a Nordin, Joel Z.u Karolinska Institutet4 aut |
700 | 1 | a Skog, Johanu Exosome Diagnost Inc, New York, NY USA.4 aut |
700 | 1 | a Romain, Charlotteu Exosome Diagnost Inc, New York, NY USA.4 aut |
700 | 1 | a Koestler, Tinau Exosome Diagnost Inc, New York, NY USA.4 aut |
700 | 1 | a Johansson Hellgren, Lailau Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)lahel172 |
700 | 1 | a Schiller, Petteru Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)pesch021 |
700 | 1 | a Joachimsson, Per-Olofu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)pejoa103 |
700 | 1 | a Hägglund, Hansu Karolinska Institutet,Uppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.4 aut0 (Swepub:uu)hanha689 |
700 | 1 | a Mattsson, Mattiasu Uppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.4 aut0 (Swepub:uu)matma431 |
700 | 1 | a Lentio, Janne4 aut |
700 | 1 | a Faridani, Omid R.u Ludwig Inst Canc Res, S-10401 Stockholm, Sweden.4 aut |
700 | 1 | a Sandberg, Rickardu Karolinska Institutet4 aut |
700 | 1 | a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors |
700 | 1 | a Krampera, Maurou Univ Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy.4 aut |
700 | 1 | a Weiss, Daniel J.u Univ Vermont, Dept Med, Hlth Sci Res Facil, Burlington, VT USA.4 aut |
700 | 1 | a Grinnemo, Karl-Henriku Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Vaccine & Gene Therapy Inst Florida, Ctr Dis Aging, Port St Lucie, FL USA.4 aut |
700 | 1 | a Le Blanc, Katarinau Karolinska Institutet4 aut |
710 | 2 | a Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.b Univ Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany.4 org |
773 | 0 | t Stem Cells Translational Medicined : Oxford University Press (OUP)g 4:10, s. 1199-1213q 4:10<1199-1213x 2157-6564x 2157-6580 |
856 | 4 | u https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0021 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265697 |
856 | 4 8 | u https://doi.org/10.5966/sctm.2015-0021 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132122757 |
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