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Collagenase clostri...
Collagenase clostridium histolyticum in patients with Dupuytren's contracture : results from POINT X, an open-label study of clinical and patient-reported outcomes
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2014-01-26
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SAGE Publications,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-266110
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-266110URI
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https://doi.org/10.1177/1753193413519926DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130618053URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In POINT X, a study designed to reflect clinical practice and patient treatment choices, 254 European patients received open-label collagenase for Dupuytren's contracture. The most severely affected joint was treated first in 74% of patients. In total, 52%, 41%, 7%, and 1% of patients selected the little, ring, middle, and index finger, respectively; 79% had one or two joints treated. Only 9% of patients (n = 24) received 4 or 5 injections. The mean improvement in total passive extension deficit (TPED) was 34° on day 1, improving further by day 7 to 42°. This secondary improvement was maintained by day 90 and month 6. The mean number of injections/joint was 1.2 for the metacarpophalangeal joint and 1.25 for the proximal interphalangeal joint. Median time to recovery was 4 days; the mean improvement in hand function was clinically relevant as measured by the Unité Rhumatologique des Affections de la Main (URAM) score. In total, 87% and 86% of patients and physicians, respectively, were very satisfied or satisfied with treatment at month 6, although correlation between TPED and patient satisfaction was weak (Spearman -0.18, 95% CI -0.32 to -0.06). Collagenase was well tolerated, with 10 (3.9%) patients experiencing severe adverse events. As a real-world study, the POINT X findings can be generalized to the at-large population.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Arner, MKarolinska Institutet
(författare)
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Pajardi, G
(författare)
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Reichert, B
(författare)
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Szabo, Z
(författare)
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Masmejean, E H
(författare)
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Fores, J
(författare)
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Chapman, D S
(författare)
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Gerber, R A
(författare)
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Huard, F
(författare)
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Seghouani, A
(författare)
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Szczypa, P P
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Hand Surgery, European Volume: SAGE Publications40:21753-19342043-6289
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Warwick, D
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Arner, M
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Pajardi, G
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Reichert, B
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Szabo, Z
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Masmejean, E H
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visa fler...
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Fores, J
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Chapman, D S
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Gerber, R A
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Huard, F
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Seghouani, A
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Szczypa, P P
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visa färre...
- Artiklar i publikationen
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Journal of Hand ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet