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Association between...
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Gunnarsson, IKarolinska Institutet
(författare)
Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus.
- Artikel/kapitelEngelska1997
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),1997
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-266926
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-266926URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1958759URI
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https://doi.org/10.1093/rheumatology/36.1.32DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-57252URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The aim of this study was to compare ongoing production of anti-C1q antibodies (anti-C1q) in peripheral blood with serum anti-C1q levels in patients with systemic lupus erythematosus (SLE), especially in patients with nephritis. Using the ELISPOT technique for the detection of IgG and IgA anti-C1q production, 21 patients with active SLE were investigated. ELISAs for IgG and IgA anti-C1q were compared with the ELISPOT results. Six of the patients were found to have proliferative nephritis (WHO grade III/IV) confirmed by renal biopsy. High numbers of IgG anti-C1q spot-forming cells (SFC), defined as > 20/10(5) plated peripheral blood mononuclear cells (PBMC), were exclusively observed in patients with proliferative nephritis (P < 0.0001). Serum levels of IgG anti-C1q were significantly increased in patients with proliferative nephritis (P = 0.039). High ongoing IgG anti-C1q production was observed in all patients with proliferative nephritis, which may be a contributory factor in the pathogenesis of this disorder. The detection of IgG anti-C1q production may be valuable in the clinical investigation of patients with suspected SLE nephritis.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rönnelid, JohanUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM(Swepub:uu)joharonn
(författare)
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Huang, Y H
(författare)
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Rogberg, S
(författare)
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Nilsson, BUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM(Swepub:uu)bonils
(författare)
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Lundberg, IKarolinska Institutet
(författare)
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Klareskog, LKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Rheumatology: Oxford University Press (OUP)36, s. 32-0263-71031460-2172
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Ingår i:Rheumatology: Oxford University Press (OUP)36, s. 32-1462-03241462-0332
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Ingår i:British Journal of Rheumatology: Oxford University Press (OUP)36, s. 32-
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