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Intestinal dysbiosi...
Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome
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- Engstrand Lilja, Helene, 1963- (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnkirurgi/Christofferson
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- Wefer, Hugo (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, S-17177 Stockholm, Sweden.
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- Nyström, Niklas (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Pediatrisk inflammationsforskning/Alving
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- Finkel, Yigael (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.;Sachs Childrens & Youth Hosp, S-11883 Stockholm, Sweden.
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- Engstrand, Lars (författare)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, S-17177 Stockholm, Sweden.;Sci Life Lab, Clin Genom Facil, S-17165 Solna, Sweden.
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(creator_code:org_t)
- 2015-05-04
- 2015
- Engelska.
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Ingår i: Microbiome. - : Springer Science and Business Media LLC. - 2049-2618. ; 3
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://microbiomejo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The composition of the intestinal microbiota seems to be an important factor in determining the clinical outcome in children with short bowel syndrome (SBS). Alterations in the microbiota may result in serious complications such as small bowel bacterial overgrowth (SBBO) and intestinal mucosal inflammation that lead to prolonged parenteral nutrition (PN) dependency with subsequently increased risk of liver failure and sepsis. To date, there are no reported mappings of the intestinal microbiome in children with SBS. Here, we present the first report on the intestinal microbial community profile in children with SBS. Findings: The study includes children diagnosed with SBS in the neonatal period. Healthy siblings served as controls. Fecal samples were collected, and microbial profiles were analyzed by using 16S rRNA gene sequencing on the Illumina MiSeq platform. We observed a pronounced microbial dysbiosis in children with SBS on PN treatment with an increased and totally dominating relative abundance of Enterobacteriacae in four out of five children compared to children with SBS weaned from PN and healthy siblings. Conclusions: The overall decreased bacterial diversity in children with SBS is consistent with intestinal microbiome mappings in inflammatory bowel diseases such as Crohn's disease and necrotizing enterocolitis in preterm infants. Our findings indicate that intestinal dysbiosis in children with SBS is associated with prolonged PN dependency.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Dysbiosis
- Short bowel syndrome
- Bacterial diversity
- Gut microbiota
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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