Sökning: onr:"swepub:oai:DiVA.org:uu-268725" >
The Expression of T...
The Expression of Transthyretin and Amyloid-beta Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients
-
- Laitera, Tiina (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland.
-
- Kurki, Mitja I. (författare)
- Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland.
-
- Pursiheimo, Juha-Pekka (författare)
- Univ Turku, Inst Biomed, Turku, Finland.
-
visa fler...
-
- Zetterberg, Henrik (författare)
- Univ Gothenburg, Sahlgrenska Acad, Clin Neurochem Lab, Dept Psychiat & Neurochem, Gothenburg, Sweden.
-
- Helisalmi, Seppo (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.
-
- Rauramaa, Tuomas (författare)
- Univ Eastern Finland, Inst Clin Med Pathol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland.
-
- Alafuzoff, Irina (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Remes, Anne M. (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.
-
- Soininen, Hilkka (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.
-
- Haapasalo, Annakaisa (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.;AI Virtanen Inst Mol Sci, Dept Neurobiol, Kuopio, Finland.
-
- Jaaskelainen, Juha E. (författare)
- Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland.
-
- Hiltunen, Mikko (författare)
- Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.;Univ Eastern Finland, Inst Biomed, Kuopio, Finland.
-
- Leinonen, Ville (författare)
- Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland.
-
visa färre...
-
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland;Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland.;Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland. Univ Eastern Finland, Inst Clin Med Neurosurg, Kuopio, Finland.;Kuopio Univ Hosp, Neurosurg NeuroCtr, SF-70210 Kuopio, Finland. (creator_code:org_t)
- 2015
- 2015
- Engelska.
-
Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 48:4, s. 959-968
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Idiopathic normal pressure hydrocephalus (iNPH) is a dementing condition in which Alzheimer's disease (AD)related amyloid-beta (A beta) plaques are frequently observed in the neocortex. iNPH patients with prominent A beta pathology show AD-related alterations in amyloid-beta protein precursor (A beta PP) processing resulting from increased gamma-secretase activity. Objectives: Our goal was to assess potential alterations in the global gene expression profile in the brain of iNPH patients as compared to non-demented controls and to evaluate the levels of the identified targets in the cerebrospinal fluid (CSF) of iNPH patients. Methods: The genome-wide expression profile of similar to 35,000 probes was assessed in the RNA samples obtained from 22 iNPH patients and eight non-demented control subjects using a microarray chip. The soluble levels of sA beta PP alpha, sA beta PP beta, and transthyretin (TTR) were measured from the CSF of 102 iNPH patients using ELISA. Results: After correcting the results for multiple testing, significant differences in the expression of TTR and A beta PP were observed between iNPH and control subjects. The mRNA levels of TTR were on average 17-fold lower in iNPH samples compared to control samples. Conversely, the expression level of A beta PP was on average three times higher in iNPH samples as compared to control samples. Interestingly, the expression of beta-secretase (ADAM10) was also increased in iNPH patients. In the lumbar CSF samples, soluble TTR levels showed a significant positive correlation with sA beta PP alpha and sA beta PP beta, but TTR levels did not predict the brain pathology or the shunt response. Conclusions: These findings suggest differences in the expression profile of key factors involved in AD-related cellular events in the brain of iNPH patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- amyloid-beta protein precursor
- gene expression profiling
- idiopathic normal pressure hydrocephalus
- transthyretin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Laitera, Tiina
-
Kurki, Mitja I.
-
Pursiheimo, Juha ...
-
Zetterberg, Henr ...
-
Helisalmi, Seppo
-
Rauramaa, Tuomas
-
visa fler...
-
Alafuzoff, Irina
-
Remes, Anne M.
-
Soininen, Hilkka
-
Haapasalo, Annak ...
-
Jaaskelainen, Ju ...
-
Hiltunen, Mikko
-
Leinonen, Ville
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Journal of Alzhe ...
- Av lärosätet
-
Uppsala universitet