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Parental smoking an...
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Thacher, Jesse DInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
(författare)
Parental smoking and development of allergic sensitization from birth to adolescence
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2015-11-13
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Wiley,2016
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-270379
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-270379URI
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https://doi.org/10.1111/all.12792DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132842968URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.METHODS: We included 3316 children from a birth cohort followed for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored using logistic regression and generalized estimating equations.RESULTS: Exposure to SHS in infancy without prior exposure in utero, was associated with an excess risk of food sensitization at age 4 (OR 1.47, 95% CI 1.08-2.00), with comparable ORs at ages 8 and 16 years. In longitudinal analyses, an overall association was indicated between SHS in infancy and food sensitization up to age 16 years (OR 1.24, 95% CI 0.98-1.56). Maternal smoking during pregnancy was unrelated to sensitization up to 16 years of age. When sensitization was combined with concurrent symptoms of allergic disease, SHS in infancy was associated with an overall elevated risk of eczema with sensitization (OR 1.62, 95% CI 1.20-2.18).CONCLUSIONS: SHS exposure in infancy appears to increase the risk of sensitization to food allergens up to age 16 years as well as eczema in combination with sensitization.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gruzieva, OlenaKarolinska Institutet
(författare)
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Pershagen, GöranKarolinska Institutet
(författare)
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Neuman, ÅsaUppsala universitet,Institutionen för kvinnors och barns hälsa,Pediatrisk inflammationsforskning/Alving(Swepub:uu)asane642
(författare)
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van Hage, MarianneKarolinska Institutet
(författare)
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Wickman, MagnusKarolinska Institutet
(författare)
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Kull, IngerKarolinska Institutet
(författare)
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Melén, ErikKarolinska Institutet
(författare)
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Bergström, AnnaKarolinska Institutet
(författare)
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Karolinska InstitutetInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Allergy. European Journal of Allergy and Clinical Immunology: Wiley71:2, s. 239-2480105-45381398-9995
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