The change in the electronic character upon cisplatin binding to guanine nucleotide is transmitted to drive the conformation of the local sugar-phosphate backbone - a quantitative study

• The microstructure alteration as a result of cisplatin binding to N7 of guanines in DNA has been herein assessed through the multinuclear temperature-, pH*- and concentration-dependent NMR study of the effect of Pt2+ complexation to 2'-deoxyguanosine 3',5

Nyckelord

NUCLEIC-ACID CONSTITUENTS; METAL-ION-BINDING; COUPLING-CONSTANTS; ANTICANCER DRUGS; AQUEOUS-SOLUTION; TORSION ANGLE; PSEUDOROTATIONAL EQUILIBRIUM; PENTOFURANOSE MOIETY; MAGNETIC-RESONANCE; CHEMICAL SYNTHESIS

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