POOR HYDRATION ENHANCES THE ACTIVATION-ENERGY OF THE EXCHANGE-RATE OF THE BASE-PAIRED IMINO PROTONS WITH WATER AT THE CORE PART OF THE DNA DUPLEX

• Here we report the exchange rates (k(ex)) of imino protons of d[5(5')p(T(1)G(2)T(3)T(4)T(5)G(6)G(7)C(8))(3')]: d[(3')(A(15)C(14)A(13)A(12)A(11)C(10)C-9)p(5')] (duplex I) with water at different pH and temperature to give the life-times (tau(o)) of the clo

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D(C-G-C-G-A-A-T-T-C-G-C-G) DOUBLE HELIX; HYBRID OLIGONUCLEOTIDE HELICES; PROTEIN HYDRATION; NMR-SPECTROSCOPY; NOE SPECTROSCOPY; AQUEOUS-SOLUTION; ROTATING-FRAME; BOUND WATER; KINETICS; OFFSET

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