Sökning: onr:"swepub:oai:DiVA.org:uu-275672" > New loci for body f...
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000 | 15812naa a2203709 4500 | |
001 | oai:DiVA.org:uu-275672 | |
003 | SwePub | |
008 | 160204s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-118411 | |
009 | oai:lup.lub.lu.se:373b5228-6423-49ed-b4a6-dbff3207561d | |
009 | oai:prod.swepub.kib.ki.se:133058788 | |
009 | oai:gup.ub.gu.se/243491 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2756722 URI |
024 | 7 | a https://doi.org/10.1038/ncomms104952 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1184112 URI |
024 | 7 | a https://lup.lub.lu.se/record/88295412 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1330587882 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2434912 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lu, Yingchang4 aut |
245 | 1 0 | a New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk |
264 | c 2016-02-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
653 | a C reactive protein; CRTC1 protein; glucose; GRB14 protein; high density lipoprotein cholesterol; IGF2BP1 protein; insulin; leptin; low density lipoprotein cholesterol; PLA2G6 protein; protein; triacylglycerol; unclassified drug | |
700 | 1 | a Day, Felix R4 aut |
700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Na, Jianbo4 aut |
700 | 1 | a Bataille, Veronique4 aut |
700 | 1 | a Cousminer, Diana L4 aut |
700 | 1 | a Dastani, Zari4 aut |
700 | 1 | a Drong, Alexander W4 aut |
700 | 1 | a Esko, Tõnu4 aut |
700 | 1 | a Evans, David M4 aut |
700 | 1 | a Falchi, Mario4 aut |
700 | 1 | a Feitosa, Mary F4 aut |
700 | 1 | a Ferreira, Teresa4 aut |
700 | 1 | a Hedman, Åsa Ku Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ashed124 |
700 | 1 | a Haring, Robin4 aut |
700 | 1 | a Hysi, Pirro G4 aut |
700 | 1 | a Iles, Mark M4 aut |
700 | 1 | a Justice, Anne E4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
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700 | 1 | a Locke, Adam4 aut |
700 | 1 | a Lu, Chen4 aut |
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700 | 1 | a Scott, William R4 aut |
700 | 1 | a Shungin, Dmitryu Lund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-dsn |
700 | 1 | a Teumer, Alexander4 aut |
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700 | 1 | a Walker, Ryan W4 aut |
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700 | 1 | a Michaëlsson, Karlu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich |
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700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
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700 | 1 | a Ong, Ken K4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Richards, J Brent4 aut |
700 | 1 | a Schadt, Eric E4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Widén, Elisabeth4 aut |
700 | 1 | a Willer, Cristen J4 aut |
700 | 1 | a Yang, Jian4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Hirschhorn, Joel N4 aut |
700 | 1 | a Pospisilik, John Andrew4 aut |
700 | 1 | a Zillikens, M Carola4 aut |
700 | 1 | a Lindgren, Cecilia4 aut |
700 | 1 | a Kilpeläinen, Tuomas Oskari4 aut |
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710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 7q 7x 2041-1723 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:900714/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/ncomms10495.pdf |
856 | 4 | u https://doi.org/10.1038/ncomms10495y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:918534/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26833246?dopt=Abstractx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/ncomms10495y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275672 |
856 | 4 8 | u https://doi.org/10.1038/ncomms10495 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118411 |
856 | 4 8 | u https://lup.lub.lu.se/record/8829541 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133058788 |
856 | 4 8 | u https://gup.ub.gu.se/publication/243491 |
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