New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

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Fältnamn	Indikatorer	Metadata
000		07632naa a2202029 4500
001		oai:DiVA.org:uu-278379
003		SwePub
008		160224s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2783792 URI
024	7	a https://doi.org/10.1038/ng.24772 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Horikoshi, Momoko4 aut
245	1 0	a New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
264		c 2012-12-02
264	1	b Springer Science and Business Media LLC,c 2013
338		a print2 rdacarrier
520		a Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
700	1	a Yaghootkar, Hanieh4 aut
700	1	a Mook-Kanamori, Dennis O4 aut
700	1	a Sovio, Ulla4 aut
700	1	a Taal, H Rob4 aut
700	1	a Hennig, Branwen J4 aut
700	1	a Bradfield, Jonathan P4 aut
700	1	a St Pourcain, Beate4 aut
700	1	a Evans, David M4 aut
700	1	a Charoen, Pimphen4 aut
700	1	a Kaakinen, Marika4 aut
700	1	a Cousminer, Diana L4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Kreiner-Møller, Eskil4 aut
700	1	a Warrington, Nicole M4 aut
700	1	a Bustamante, Mariona4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Berry, Diane J4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Pfab, Thiemo4 aut
700	1	a Barton, Sheila J4 aut
700	1	a Shields, Beverley M4 aut
700	1	a Kerkhof, Marjan4 aut
700	1	a van Leeuwen, Elisabeth M4 aut
700	1	a Fulford, Anthony J4 aut
700	1	a Kutalik, Zoltán4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a den Hoed, Marcel4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a Lindi, Virpi4 aut
700	1	a Goh, Liang-Kee4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a Wu, Ying4 aut
700	1	a Raitakari, Olli T4 aut
700	1	a Harder, Marie N4 aut
700	1	a Meirhaeghe, Aline4 aut
700	1	a Ntalla, Ioanna4 aut
700	1	a Salem, Rany M4 aut
700	1	a Jameson, Karen A4 aut
700	1	a Zhou, Kaixin4 aut
700	1	a Monies, Dorota M4 aut
700	1	a Lagou, Vasiliki4 aut
700	1	a Kirin, Mirna4 aut
700	1	a Heikkinen, Jani4 aut
700	1	a Adair, Linda S4 aut
700	1	a Alkuraya, Fowzan S4 aut
700	1	a Al-Odaib, Ali4 aut
700	1	a Amouyel, Philippe4 aut
700	1	a Andersson, Ehm Astrid4 aut
700	1	a Bennett, Amanda J4 aut
700	1	a Blakemore, Alexandra I F4 aut
700	1	a Buxton, Jessica L4 aut
700	1	a Dallongeville, Jean4 aut
700	1	a Das, Shikta4 aut
700	1	a de Geus, Eco J C4 aut
700	1	a Estivill, Xavier4 aut
700	1	a Flexeder, Claudia4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Geller, Frank4 aut
700	1	a Godfrey, Keith M4 aut
700	1	a Gottrand, Frédéric4 aut
700	1	a Groves, Christopher J4 aut
700	1	a Hansen, Torben4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Hofman, Albert4 aut
700	1	a Hollegaard, Mads V4 aut
700	1	a Hougaard, David M4 aut
700	1	a Hyppönen, Elina4 aut
700	1	a Inskip, Hazel M4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Jørgensen, Torben4 aut
700	1	a Kanaka-Gantenbein, Christina4 aut
700	1	a Kemp, John P4 aut
700	1	a Kiess, Wieland4 aut
700	1	a Kilpeläinen, Tuomas O4 aut
700	1	a Klopp, Norman4 aut
700	1	a Knight, Bridget A4 aut
700	1	a Kuzawa, Christopher W4 aut
700	1	a McMahon, George4 aut
700	1	a Newnham, John P4 aut
700	1	a Niinikoski, Harri4 aut
700	1	a Oostra, Ben A4 aut
700	1	a Pedersen, Louise4 aut
700	1	a Postma, Dirkje S4 aut
700	1	a Ring, Susan M4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Robertson, Neil R4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Simell, Olli4 aut
700	1	a Slowinski, Torsten4 aut
700	1	a Tiesler, Carla M T4 aut
700	1	a Tönjes, Anke4 aut
700	1	a Vaag, Allan4 aut
700	1	a Viikari, Jorma S4 aut
700	1	a Vink, Jacqueline M4 aut
700	1	a Vissing, Nadja Hawwa4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Witte, Daniel R4 aut
700	1	a Zhang, Haitao4 aut
700	1	a Zhao, Jianhua4 aut
700	1	a Wilson, James F4 aut
700	1	a Stumvoll, Michael4 aut
700	1	a Prentice, Andrew M4 aut
700	1	a Meyer, Brian F4 aut
700	1	a Pearson, Ewan R4 aut
700	1	a Boreham, Colin A G4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Gillman, Matthew W4 aut
700	1	a Dedoussis, George V4 aut
700	1	a Moreno, Luis A4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Saarinen, Maiju4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Boomsma, Dorret I4 aut
700	1	a Saw, Seang-Mei4 aut
700	1	a Lakka, Timo A4 aut
700	1	a Körner, Antje4 aut
700	1	a Loos, Ruth J F4 aut
700	1	a Ong, Ken K4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Koppelman, Gerard H4 aut
700	1	a Hattersley, Andrew T4 aut
700	1	a Holloway, John W4 aut
700	1	a Hocher, Berthold4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Power, Chris4 aut
700	1	a Melbye, Mads4 aut
700	1	a Guxens, Mònica4 aut
700	1	a Pennell, Craig E4 aut
700	1	a Bønnelykke, Klaus4 aut
700	1	a Bisgaard, Hans4 aut
700	1	a Eriksson, Johan G4 aut
700	1	a Widén, Elisabeth4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a Pouta, Anneli4 aut
700	1	a Lawlor, Debbie A4 aut
700	1	a Smith, George Davey4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Jaddoe, Vincent W V4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Freathy, Rachel M4 aut
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 45:1q 45:1x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3605762?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278379
856	4 8	u https://doi.org/10.1038/ng.2477

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Av författaren/redakt...: Horikoshi, Momok ...; Yaghootkar, Hani ...; Mook-Kanamori, D ...; Sovio, Ulla; Taal, H Rob; Hennig, Branwen ...; visa fler...; Bradfield, Jonat ...; St Pourcain, Bea ...; Evans, David M; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana ...; Lehtimäki, Terho; Kreiner-Møller, ...; Warrington, Nico ...; Bustamante, Mari ...; Feenstra, Bjarke; Berry, Diane J; Thiering, Elisab ...; Pfab, Thiemo; Barton, Sheila J; Shields, Beverle ...; Kerkhof, Marjan; van Leeuwen, Eli ...; Fulford, Anthony ...; Kutalik, Zoltán; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke- ...; Wu, Ying; Raitakari, Olli ...; Harder, Marie N; Meirhaeghe, Alin ...; Ntalla, Ioanna; Salem, Rany M; Jameson, Karen A; Zhou, Kaixin; Monies, Dorota M; Lagou, Vasiliki; Kirin, Mirna; Heikkinen, Jani; Adair, Linda S; Alkuraya, Fowzan ...; Al-Odaib, Ali; Amouyel, Philipp ...; Andersson, Ehm A ...; Bennett, Amanda ...; Blakemore, Alexa ...; Buxton, Jessica ...; Dallongeville, J ...; Das, Shikta; de Geus, Eco J C; Estivill, Xavier; Flexeder, Claudi ...; Froguel, Philipp ...; Geller, Frank; Godfrey, Keith M; Gottrand, Frédér ...; Groves, Christop ...; Hansen, Torben; Hirschhorn, Joel ...; Hofman, Albert; Hollegaard, Mads ...; Hougaard, David ...; Hyppönen, Elina; Inskip, Hazel M; Isaacs, Aaron; Jørgensen, Torbe ...; Kanaka-Gantenbei ...; Kemp, John P; Kiess, Wieland; Kilpeläinen, Tuo ...; Klopp, Norman; Knight, Bridget ...; Kuzawa, Christop ...; McMahon, George; Newnham, John P; Niinikoski, Harr ...; Oostra, Ben A; Pedersen, Louise; Postma, Dirkje S; Ring, Susan M; Rivadeneira, Fer ...; Robertson, Neil ...; Sebert, Sylvain; Simell, Olli; Slowinski, Torst ...; Tiesler, Carla M ...; Tönjes, Anke; Vaag, Allan; Viikari, Jorma S; Vink, Jacqueline ...; Vissing, Nadja H ...; Wareham, Nichola ...; Willemsen, Gonne ...; Witte, Daniel R; Zhang, Haitao; Zhao, Jianhua; Wilson, James F; Stumvoll, Michae ...; Prentice, Andrew ...; Meyer, Brian F; Pearson, Ewan R; Boreham, Colin A ...; Cooper, Cyrus; Gillman, Matthew ...; Dedoussis, Georg ...; Moreno, Luis A; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L; Boomsma, Dorret ...; Saw, Seang-Mei; Lakka, Timo A; Körner, Antje; Loos, Ruth J F; Ong, Ken K; Vollenweider, Pe ...; van Duijn, Corne ...; Koppelman, Gerar ...; Hattersley, Andr ...; Holloway, John W; Hocher, Berthold; Heinrich, Joachi ...; Power, Chris; Melbye, Mads; Guxens, Mònica; Pennell, Craig E; Bønnelykke, Klau ...; Bisgaard, Hans; Eriksson, Johan ...; Widén, Elisabeth; Hakonarson, Hako ...; Uitterlinden, An ...; Pouta, Anneli; Lawlor, Debbie A; Smith, George Da ...; Frayling, Timoth ...; McCarthy, Mark I; Grant, Struan F ...; Jaddoe, Vincent ...; Jarvelin, Marjo- ...; Timpson, Nichola ...; Prokopenko, Inga; Freathy, Rachel ...; visa färre...

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