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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03059naa a2200301 4500 | |
| 001 | oai:DiVA.org:uu-278391 | |
| 003 | SwePub | |
| 008 | 160224s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2783912 URI |
| 024 | 7 | a https://doi.org/10.3945/ajcn.2009.280532 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a den Hoed, Marcel4 aut |
| 245 | 1 0 | a Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. |
| 264 | 1 | b Elsevier BV,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: The common rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is associated with adiposity, possibly by affecting satiety responsiveness.OBJECTIVE: The objective was to determine whether postprandial responses in hunger and satiety are associated with rs9939609, taking interactions with other relevant candidate genes into account.DESIGN: Sixty-two women and 41 men [age: 31 +/- 14 y; body mass index (in kg/m(2)): 25.0 +/- 3.1] were genotyped for 5 SNPs in FTO, DNMT1, DNMT3B, LEP, and LEPR. Individuals received fixed meals provided in energy balance. Hunger and satiety were determined pre- and postprandially by using visual analog scales.RESULTS: A general association test showed a significant association between postprandial responses in hunger and satiety with rs9939609 (P = 0.036 and P = 0.050, respectively). Individuals with low postprandial responses in hunger and satiety were overrepresented among TA/AA carriers in rs9939609 (FTO) compared with TT carriers (dominant and additive model: P = 0.013 and P = 0.020, respectively). Moreover, multifactor dimensionality reduction showed significant epistatic interactions for the postprandial decrease in hunger involving rs9939609 (FTO), rs992472 (DNMT3B), and rs1137101 (LEPR). Individuals with a low postprandial decrease in hunger were overrepresented among TA/AA (dominant), CC/CA (recessive), and AG/GG (dominant) carriers in rs9939609 (FTO), rs992472 (DNMT3B), and rs1137101 (LEPR), respectively (n = 39), compared with TT, AA, and/or AA carriers in these SNPs, respectively (P = 0.00001). Each SNP had an additional effect.CONCLUSIONS: Our results confirm a role for FTO in responsiveness to hunger and satiety cues in adults in an experimental setting. The epistatic interaction suggests that DNA methylation, an epigenetic process, affects appetite. | |
| 700 | 1 | a Westerterp-Plantenga, Margriet S4 aut |
| 700 | 1 | a Bouwman, Freek G4 aut |
| 700 | 1 | a Mariman, Edwin C M4 aut |
| 700 | 1 | a Westerterp, Klaas R4 aut |
| 773 | 0 | t American Journal of Clinical Nutritiond : Elsevier BVg 90:5q 90:5x 0002-9165x 1938-3207 |
| 856 | 4 | u https://academic.oup.com/ajcn/article-pdf/90/5/1426/23853861/1426.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278391 |
| 856 | 4 8 | u https://doi.org/10.3945/ajcn.2009.28053 |
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