Sökning: onr:"swepub:oai:DiVA.org:uu-281478" > Association Between...
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000 | 04443naa a2200445 4500 | |
001 | oai:DiVA.org:uu-281478 | |
003 | SwePub | |
008 | 160324s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:132992218 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2814782 URI |
024 | 7 | a https://doi.org/10.1007/s40261-015-0372-92 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1329922182 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hasvold, Palu AstraZeneca, S-15185 Sodertalje, Sweden.;Univ Oslo, Fac Med, N-0424 Oslo, Norway.4 aut |
245 | 1 0 | a Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting |
264 | c 2015-12-30 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a Background and Objectives Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse cardiovascular events (MACE). Methods Data from 15,357 primary care patients initiated on statins during 2004-2009 were linked with data from mandatory national hospital, drug-dispensing, and cause-of-death registers, and were grouped according to HDL-C change: decreased >= 0.1 mmol/L, unchanged +/- 0.1 or >= 0.1 mmol/L increased. To evaluate the association between decrease in HDL-C and risk of MACE, a sample of propensity score-matched patients from the decreased and unchanged groups was created, using the latter group as reference. MACE was defined as myocardial infarction, unstable angina pectoris, ischaemic stroke, or cardiovascular mortality. Cox proportional hazards models were used to estimate relative risks. Results HDL-C decreased in 20 %, was unchanged in 58%, and increased in 22 % of patients initiated on statin treatment (96 % treated with simvastatin). The propensity score-matched sample comprised 5950 patients with mean baseline HDL-C and LDL-C of 1.69 and 4.53 mmol/L, respectively. HDL-C decrease was associated with 56 % higher MACE risk (hazard ratio 1.56; 95 % confidence interval 1.12-2.16; p < 0.01) compared with the unchanged HDL-C group. Conclusions Paradoxical statin-induced reduction in HDL-C was relatively common and was associated with increased risk of MACE. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
700 | 1 | a Thuresson, Marcusu Statisticon AB, S-75322 Uppsala, Sweden.4 aut |
700 | 1 | a Sundstrom, Johanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)johasund |
700 | 1 | a Hammar, Niklasu Karolinska Institutet4 aut |
700 | 1 | a Kjeldsen, Sverre E.u Univ Oslo, Fac Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Dept Cardiol, Oslo, Norway.4 aut |
700 | 1 | a Johansson, Gunnaru Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)gunnarjs |
700 | 1 | a Holme, Ingaru Norwegian Sch Sport Sci, Dept Sports Med, POB 4014, N-0806 Oslo, Norway.4 aut |
700 | 1 | a Bodegard, Johanu AstraZeneca, S-15185 Sodertalje, Sweden.4 aut |
710 | 2 | a AstraZeneca, S-15185 Sodertalje, Sweden.;Univ Oslo, Fac Med, N-0424 Oslo, Norway.b Statisticon AB, S-75322 Uppsala, Sweden.4 org |
773 | 0 | t Clinical drug investigationd : Springer Science and Business Media LLCg 36:3, s. 225-233q 36:3<225-233x 1173-2563x 1179-1918 |
856 | 4 | u https://doi.org/10.1007/s40261-015-0372-9y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:915371/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s40261-015-0372-9.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478 |
856 | 4 8 | u https://doi.org/10.1007/s40261-015-0372-9 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132992218 |
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