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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004443naa a2200445 4500
001oai:DiVA.org:uu-281478
003SwePub
008160324s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132992218
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2814782 URI
0247 a https://doi.org/10.1007/s40261-015-0372-92 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1329922182 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hasvold, Palu AstraZeneca, S-15185 Sodertalje, Sweden.;Univ Oslo, Fac Med, N-0424 Oslo, Norway.4 aut
2451 0a Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting
264 c 2015-12-30
264 1b Springer Science and Business Media LLC,c 2016
338 a electronic2 rdacarrier
520 a Background and Objectives Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse cardiovascular events (MACE). Methods Data from 15,357 primary care patients initiated on statins during 2004-2009 were linked with data from mandatory national hospital, drug-dispensing, and cause-of-death registers, and were grouped according to HDL-C change: decreased >= 0.1 mmol/L, unchanged +/- 0.1 or >= 0.1 mmol/L increased. To evaluate the association between decrease in HDL-C and risk of MACE, a sample of propensity score-matched patients from the decreased and unchanged groups was created, using the latter group as reference. MACE was defined as myocardial infarction, unstable angina pectoris, ischaemic stroke, or cardiovascular mortality. Cox proportional hazards models were used to estimate relative risks. Results HDL-C decreased in 20 %, was unchanged in 58%, and increased in 22 % of patients initiated on statin treatment (96 % treated with simvastatin). The propensity score-matched sample comprised 5950 patients with mean baseline HDL-C and LDL-C of 1.69 and 4.53 mmol/L, respectively. HDL-C decrease was associated with 56 % higher MACE risk (hazard ratio 1.56; 95 % confidence interval 1.12-2.16; p < 0.01) compared with the unchanged HDL-C group. Conclusions Paradoxical statin-induced reduction in HDL-C was relatively common and was associated with increased risk of MACE.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
7001 a Thuresson, Marcusu Statisticon AB, S-75322 Uppsala, Sweden.4 aut
7001 a Sundstrom, Johanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)johasund
7001 a Hammar, Niklasu Karolinska Institutet4 aut
7001 a Kjeldsen, Sverre E.u Univ Oslo, Fac Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Dept Cardiol, Oslo, Norway.4 aut
7001 a Johansson, Gunnaru Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)gunnarjs
7001 a Holme, Ingaru Norwegian Sch Sport Sci, Dept Sports Med, POB 4014, N-0806 Oslo, Norway.4 aut
7001 a Bodegard, Johanu AstraZeneca, S-15185 Sodertalje, Sweden.4 aut
7102 a AstraZeneca, S-15185 Sodertalje, Sweden.;Univ Oslo, Fac Med, N-0424 Oslo, Norway.b Statisticon AB, S-75322 Uppsala, Sweden.4 org
7730 t Clinical drug investigationd : Springer Science and Business Media LLCg 36:3, s. 225-233q 36:3<225-233x 1173-2563x 1179-1918
8564 u https://doi.org/10.1007/s40261-015-0372-9y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:915371/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007/s40261-015-0372-9.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478
8564 8u https://doi.org/10.1007/s40261-015-0372-9
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132992218

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