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The clinical perspe...
The clinical perspective on malignancies in renal transplanted patients
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- Hellström, Vivan (författare)
- Uppsala universitet,Transplantationskirurgi
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- Lorant, Tomas (preses)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Tufveson, Gunnar (preses)
- Uppsala universitet,Transplantationskirurgi
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- Enblad, Gunilla (preses)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Lindnér, Per (opponent)
- Sahlgrenska Academy; Institute of Clinical Sciences; Department of Surgery
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(creator_code:org_t)
- ISBN 9789155495497
- Uppsala : Acta Universitatis Upsaliensis, 2016
- Engelska 82 s.
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Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 1210
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Abstract
Ämnesord
Stäng
- Post-transplant malignancies cause significant morbidity and mortality. In this thesis we investigated malignancies in renal transplanted patients from a clinical viewpoint. The use of regional tumour registries considerably improved identification of pre- and post-transplant malignancies, which are generally underreported in transplant registries.Despite previously adequate cancer treatments with favourable prognosis, patients with pre-transplant malignancies showed higher incidence of post-transplant cancer and reduced survival compared to a 1:3 ratio matched control group of patients without a previous cancer from the Collaborative Transplant Study in Europe. A careful oncological surveillance pre-transplant and post-transplant is recommended.A multidisciplinary team evaluated the immunosuppressive and oncological treatment in a clinical prospective observational study of 120 renal transplanted patients with post-transplant malignancies. In two-thirds of the patients immunosuppression was possible to change to mTOR inhibitors with anti-tumour effects. Oncological treatment was adjusted in 50% of patients with solid or haematological tumours. MDT assessments are essential for optimizing treatment of post-transplant malignancies.Number of previous cutaneous squamous cell carcinoma (SCC) posed the most significant risk variable in predicting subsequent SCCs during a two-years study of 73 transplanted patients with at least one SCC.Incidence of transplant-derived tumours is 5 times higher than anticipated. Three of eleven cancers in urinary tract and two of four cancers in the transplants were transplant-derived. Five of eleven cancers of the urinary tract were BK-virus positive. Allograft immune response against these tumours offer new options for cancer treatment such as immunomodulatory or anti-viral treatment in combination with modified immunosuppression.
Nyckelord
- renal transplantation
- malignant tumours
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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