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Lipid-lowering trea...
Lipid-lowering treatment patterns in patients with new cardiovascular events - estimates from population-based register data in Sweden
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- Hallberg, S. (författare)
- Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden.,Quantify Research, Sweden
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- Banefelt, J. (författare)
- Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden.,Quantify Research, Sweden
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- Fox, K. M. (författare)
- Strateg Healthcare Solut LLC, Baltimore, MD USA.
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- Mesterton, J. (författare)
- Karolinska Institutet
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- Johansson, Gunnar (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Sweden
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- Levin, Lars-Åke (författare)
- Linköpings universitet,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten
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- Sobocki, P. (författare)
- Karolinska Inst, LIME Med Management Ctr, Stockholm, Sweden.;IMS Hlth, Stockholm, Sweden.,Karolinska Institute, Sweden; IMS Heatlh, Sweden
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- Gandra, S. R. (författare)
- Amgen Inc, Thousand Oaks, CA 91320 USA.
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Quantify Res, Hantverkargatan 8, S-11221 Stockholm, Sweden Quantify Research, Sweden (creator_code:org_t)
- 2016-01-22
- 2016
- Engelska.
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Ingår i: International journal of clinical practice (Esher). - : Hindawi Limited. - 1368-5031 .- 1742-1241. ; 70:3, s. 222-228
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- ObjectivesThe aim of this study was to assess treatment patterns of lipid-lowering therapy (LLT) in patients with hyperlipidaemia or prior cardiovascular (CV) events who experience new CV events. MethodsA retrospective population-based cohort study was conducted using Swedish medical records and registers. Patients were included in the study based on a prescription of LLT or CV event history and followed up for up to 7 years for identification of new CV events and assessment of LLT treatment patterns. Patients were stratified into three cohorts based on CV risk level. All outcomes were assessed during the year following index (the date of first new CV event). Adherence was defined as medication possession ratio (MPR) > 0.80. Persistence was defined as no gaps > 60 days in supply of drug used at index. ResultsOf patients with major cardiovascular disease (CVD) history (n = 6881), 49% were not on LLT at index. Corresponding data for CV risk equivalent and low/unknown CV risk patients were 37% (n = 3226) and 38% (n = 2497) respectively. MPR for patients on LLT at index was similar across cohorts (0.74-0.75). The proportions of adherent (60-63%) and persistent patients (56-57%) were also similar across cohorts. Dose escalation from dose at index was seen within all cohorts and 2-3% of patients switched to a different LLT after index while 5-6% of patients augmented treatment by adding another LLT. ConclusionsAlmost 50% of patients with major CVD history were not on any LLT, indicating a potential therapeutic gap. Medication adherence and persistence among patients on LLT were suboptimal.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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