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Function and Gene E...
Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
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- Espes, Daniel, 1985- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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- Liljebäck, Hanna (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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- Franzén, Petra (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Quach, My (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Lau, Joey, 1979- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantationskirurgi
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(creator_code:org_t)
- 2020-12-01
- 2020
- Engelska.
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Ingår i: Cell Transplantation. - THOUSAND OAKS, CA USA : SAGE Publications. - 0963-6897 .- 1555-3892. ; 29, s. 1-10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Islet transplantation to the liver is a potential curative treatment for patients with type 1 diabetes. Muscle and the greater omentum are two alternative implantation sites, which can provide excellent engraftment and hold potential as future sites for stem-cell-derived beta-cell replacement. We evaluated the functional outcome after islet transplantation to muscle and omentum and found that alloxan-diabetic animals were cured with a low number of islets (200) at both sites. The cured animals had a normal area under the curve blood glucose response to intravenous glucose, albeit animals with intramuscular islet grafts had increased 120-min blood glucose levels. They also demonstrated an exaggerated counter regulatory response to hypoglycemia. The expression of genes important for beta-cell function was, at both implantation sites, comparable to that in native pancreatic islets. The gene expression of insulin (INS1 and INS2) and glucose transporter-2 was even increased, and the expression of lactate dehydrogenase decreased, at both sites when compared to native islets. We conclude that muscle and omentum provide excellent conditions for engraftment of transplanted islets. When compared to control, 200 islets implanted to the omentum displayed a restored glucose tolerance, whereas animals with intramuscular islet grafts of similar size displayed mild glucose intolerance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Islet transplantation
- muscle
- omentum
- engraftment
- gene expression
- laser capture microdissection
- Medical Cell Biology
- Medicinsk cellbiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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