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Small and large fib...
Small and large fiber neuropathy in those with type 1 and type 2 diabetes : a 5-year follow-up study
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- Løseth, Sissel (författare)
- Univ Hosp North Norway, Dept Neurol & Neurophysiol, N-9038 Tromso, Norway.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
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- Stålberg, Erik V. (författare)
- Uppsala universitet,Klinisk neurofysiologi
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- Lindal, Sigurd (författare)
- Univ Hosp North Norway, Dept Clin Pathol, N-9038 Tromso, Norway.;Arctic Univ Norway, Dept Med Biol, Tromso, Norway.
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- Olsen, Edel (författare)
- Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
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- Jorde, Rolf (författare)
- Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Univ Hosp North Norway, Dept Internal Med, N-9038 Tromso, Norway.
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- Mellgren, Svein I. (författare)
- Univ Hosp North Norway, Dept Neurol & Neurophysiol, N-9038 Tromso, Norway.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
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Univ Hosp North Norway, Dept Neurol & Neurophysiol, N-9038 Tromso, Norway;Arctic Univ Norway, Dept Clin Med, Tromso, Norway. Klinisk neurofysiologi (creator_code:org_t)
- 2016-03-01
- 2016
- Engelska.
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Ingår i: Journal of the peripheral nervous system. - : Wiley. - 1085-9489 .- 1529-8027. ; 21:1, s. 15-21
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The purpose of this study was to evaluate progression of diabetic polyneuropathy and differences in the spectrum and evolution of large- and small-fiber involvement in patients with diabetes type 1 and 2 over 5 years. Fifty-nine patients (35 type 1 and 24 type 2) were included. Nerve conduction studies (NCS), quantitative sensory testing, skin biopsy for quantification of intraepidermal nerve fiber density (IENFD), symptom scoring and clinical evaluations were performed. Z-scores were calculated to adjust for the physiologic effects of age and height/gender. Neuropathic symptoms were not significantly more frequent in type 2 than in type 1 diabetic patients at follow-up (54% vs. 37%). The overall mean NCS Z-score remained within the normal range, but there was a small significant decline after 5 years in both groups: type 1 (p = 0.004) and type 2 (p = 0.02). Mean IENFD Z-scores changed from normal to abnormal in both groups, but only significantly in those with type 2 diabetes (reduction from 7.9 +/- 4.8 to 4.3 +/- 2.8 fibers/mm, p = 0.006). Cold perception threshold became more abnormal only in those with type 2 diabetes (p = 0.049). There was a minimal progression of large fiber neuropathy in both groups. Reduction of small fibers predominated and progressed more rapidly in those with type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- diabetes
- follow-up study
- nerve conduction studies
- neuropathy
- skin biopsy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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