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Complement Receptor...
Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function
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- Lindblom, Rickard, 1981- (författare)
- Uppsala universitet,Thoraxkirurgi,Karolinska Institutet;Uppsala University
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- Aeinehband, Shahin (författare)
- Karolinska Inst, Neuroimmunol Unit, Dept Clin Neurosci, S-10401 Stockholm, Sweden,Karolinska Institutet
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- Ström, Mikael (författare)
- Karolinska Inst, Neuroimmunol Unit, Dept Clin Neurosci, S-10401 Stockholm, Sweden,Karolinska Institutet
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- Al Nimer, Faiez (författare)
- Karolinska Institutet
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- Sandholm, Kerstin (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC
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- Khademi, Mohsen (författare)
- Karolinska Institutet
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- Nilsson, Bo (författare)
- Uppsala universitet,Klinisk immunologi,Uppsala University
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- Piehl, Fredrik (författare)
- Karolinska Institutet
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- Ekdahl Nilsson, Kristina (författare)
- Linnéuniversitetet,Uppsala universitet,Klinisk immunologi,Institutionen för kemi och biomedicin (KOB),Uppsala University,Linnaeus Ctr Biomat Chem, BMC
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Clinical Immunology. - : Elsevier BV. - 1521-6616 .- 1521-7035. ; 166, s. 89-95
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Besides its vital role in immunity, the complement system also contributes to the shaping of the synaptic circuitry of the brain. We recently described that soluble Complement Receptor 2 (sCR2) is part of the nerve injury response in rodents. We here study CR2 in context of multiple sclerosis (MS) and explore the molecular effects of CR2 on 0 activation. Significant increases in sCR2 levels were evident in cerebrospinal fluid (CSF) from both patients with relapsing remitting MS (n = 33; 6.2 ng/mL) and secondary-progressive MS (n = 9; 7.0 ng/mL) as compared to controls (n = 18; 4.1 ng/mL). Furthermore, CSF sCR2 levels correlated significantly both with CSF C3 and C1q as well as to a disease severity measure. In vitro, sCR2 inhibited the cleavage and down regulation of Cab to iC3b, suggesting that it exerts a modulatory role in complement activation downstream of C3. These results propose a novel function for CR2/sCR2 in human neuroinflammatory conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Complement Receptor 2; Complement system; Multiple sclerosis; Neurodegeneration; Neuroinflammation
- Medicinsk vetenskap
- Medical Science
- Immunologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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