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18F-FDG PET/CT Diag...
18F-FDG PET/CT Diagnosis of Bronchopulmonary Carcinoids Versus Pulmonary Hamartomas
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- Uhlen, Natalja (författare)
- Dept Clin Sci Intervent & Technol, Div Radiog, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Radiol, Huddinge, Sweden.
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- Grundberg, Oscar (författare)
- Karolinska Institutet
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- Jacobsson, Hans (författare)
- Karolinska Institutet
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- Sundin, Anders (författare)
- Uppsala universitet,Radiologi,Univ Uppsala Hosp, Dept Radiol, Uppsala, Sweden
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- Dobra, Katalin (författare)
- Karolinska Institutet
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- Sanchez-Crespo, Alejandro (författare)
- Karolinska Univ Hosp, Dept Nucl Med, SE-14186 Stockholm, Sweden.
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- Axelsson, Rimma (författare)
- Karolinska Institutet
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- Kolbeck, Karl-Gustaf (författare)
- Karolinska Institutet
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Karolinska Institutet Dept Clin Sci Intervent & Technol, Div Radiog, Stockholm, Sweden;Karolinska Univ Hosp, Dept Radiol, Huddinge, Sweden. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Clinical Nuclear Medicine. - 0363-9762 .- 1536-0229. ; 41:4, s. 263-267
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose Radiological characterization of pulmonary tumors may be difficult and invasive. Needle biopsy may produce false-negative results. F-18-FDG PET/CT is an established noninvasive procedure for lung tumor characterization and staging. This study was aimed at differentiating bronchopulmonary carcinoids from hamartomas and typical from atypical bronchopulmonary carcinoids by means of F-18-FDG PET/CT. Patients and Methods In a retrospective analysis of 118 patients, with surgically resected pulmonary carcinoid tumors and hamartomas, 87 of those selected had also undergone F-18-FDG PET/CT preoperatively and constituted the study population. To better assess the tracer accumulation, especially in small lesions, the F-18-FDG uptake (SUV) in the tumors was corrected for partial volume effect by applying recovery coefficients corresponding to the respective various specific tumor volumes, as extrapolated from those obtained from experiments in a NEMA phantom. Results The SUVmax was higher in the pulmonary carcinoids (mean, 3.9) than in the hamartomas (mean, 1.4; P <= 0.00001) and higher in the subgroup of peripheral carcinoids than in hamartomas (P <= 0.00001). The SUVmax was similar for the atypical and typical carcinoids, 5.0 and 3.8, respectively, because of the large variation in the data (P = 0.11). Conclusions Using PET measurements of the F-18-FDG uptake (SUVmax) in the tumors, corrected for partial volume effects, it was possible to differentiate the carcinoids from the hamartomas, but the clinically more aggressive atypical carcinoids could not be differentiated from the typical carcinoids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- SUV correction
- hamartoma
- pulmonary carcinoid tumor
- F-18-FDG PET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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