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Lipocalin 2 produce...
Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue
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- Kamble, Prasad G. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Pereira, Maria J. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Sidibeh, Cherno O. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Amini, Sam (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Sundbom, Magnus (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Börjesson, Joey Lau (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Eriksson, Jan W. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207 .- 1872-8057. ; 427, s. 124-132
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPAR gamma and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess.
Nyckelord
- Glucocorticoids
- Lipocalin 2
- Human adipose tissue
- Type 2 diabetes
- Insulin resistance
- PPAR gamma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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