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Blood-Pressure Lowe...
Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease
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- Lonn, Eva M. (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
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- Bosch, Jackie (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada.
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- Lopez-Jaramillo, Patricio (författare)
- Univ Santander, Fdn Oftalmol Santander, Bucaramanga, Colombia.;Univ Santander, Sch Med, Inst Masira, Bucaramanga, Colombia.
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- Zhu, Jun (författare)
- Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
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- Liu, Lisheng (författare)
- Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
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- Pais, Prem (författare)
- St Johns Res Inst, Bangalore, Karnataka, India.
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- Diaz, Rafael (författare)
- Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina.
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- Xavier, Denis (författare)
- St Johns Res Inst, Bangalore, Karnataka, India.;St Johns Med Coll, Bangalore, Karnataka, India.
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- Sliwa, Karen (författare)
- Univ Cape Town, Soweto Cardiovasc Res Grp, Dept Med, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, South Africa.
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- Dans, Antonio (författare)
- Univ Philippines, Coll Med, Manila, Philippines.
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- Avezum, Alvaro (författare)
- Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
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- Piegas, Leopoldo S. (författare)
- HCor Heart Hosp, Sao Paulo, Brazil.
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- Keltai, Katalin (författare)
- Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary.
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- Keltai, Matyas (författare)
- Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary.
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- Chazova, Irina (författare)
- Inst Clin Cardiol, Russian Cardiol Res Complex, Moscow, Russia.
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- Peters, Ron J. G. (författare)
- Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
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- Held, Claes (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Yusoff, Khalid (författare)
- Univ Teknol Majlis Amansh Rakyat, Selayang, Malaysia.;Univ Coll Sedaya Int Univ, Kuala Lumpur, Malaysia.
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- Lewis, Basil S. (författare)
- Technion Israel Inst Technol, Lady Davis Carmel Med Ctr, Ruth & Bruce Rappaport Sch Med, Haifa, Israel.
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- Jansky, Petr (författare)
- Univ Hosp Motol, Prague, Czech Republic.
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- Parkhomenko, Alexander (författare)
- Inst Cardiol, Kiev, Ukraine.
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- Khunti, Kamlesh (författare)
- Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
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- Toff, William D. (författare)
- Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Leicester Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, Leicester, Leics, England.
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- Reid, Christopher M. (författare)
- Monash Univ, Monash Ctr Cardiovasc Res & Educ Therapeut, Primary Care Diabet & Vasc Med, Melbourne, Vic 3004, Australia.;Curtin Univ, Sch Publ Hlth, Perth, WA 6845, Australia.
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- Varigos, John (författare)
- Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
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- Leiter, Lawrence A. (författare)
- Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.;Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada.
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- Molina, Dora I. (författare)
- Univ Caldas, Manizales, Colombia.;Inst Prestadora Salud Internistas Caldas, Manizales, Colombia.
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- McKelvie, Robert (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
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- Pogue, Janice (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada.
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- Wilkinson, Joanne (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Jung, Hyejung (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Dagenais, Gilles (författare)
- Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada.
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- Yusuf, Salim (författare)
- McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
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McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;McMaster Univ, Dept Med, Hamilton, ON, Canada. McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 374:21, s. 2009-2020
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its role in persons at intermediate risk and with lower blood pressure is unclear.METHODS In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years.RESULTS The mean blood pressure of the participants at baseline was 138.1/81.9 mm Hg; the decrease in blood pressure was 6.0/3.0 mm Hg greater in the active-treatment group than in the placebo group. The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.79 to 1.10; P = 0.40); the second coprimary outcome occurred in 312 participants (4.9%) and 328 participants (5.2%), respectively (hazard ratio, 0.95; 95% CI, 0.81 to 1.11; P = 0.51). In one of the three prespecified hypothesis-based subgroups, participants in the subgroup for the upper third of systolic blood pressure (>143.5 mm Hg) who were in the active-treatment group had significantly lower rates of the first and second coprimary outcomes than those in the placebo group; effects were neutral in the middle and lower thirds (P = 0.02 and P = 0.009, respectively, for trend in the two outcomes).CONCLUSIONS Therapy with candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day was not associated with a lower rate of major cardiovascular events than placebo among persons at intermediate risk who did not have cardiovascular disease. ( ClinicalTrials. gov number, NCT00468923.)
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Lonn, Eva M.
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Bosch, Jackie
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Lopez-Jaramillo, ...
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Zhu, Jun
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Liu, Lisheng
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Pais, Prem
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Diaz, Rafael
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Xavier, Denis
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Sliwa, Karen
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Dans, Antonio
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Avezum, Alvaro
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Piegas, Leopoldo ...
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Keltai, Katalin
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Keltai, Matyas
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Chazova, Irina
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Peters, Ron J. G ...
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Held, Claes
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Yusoff, Khalid
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Lewis, Basil S.
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Jansky, Petr
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Parkhomenko, Ale ...
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Khunti, Kamlesh
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Toff, William D.
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Reid, Christophe ...
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Varigos, John
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Leiter, Lawrence ...
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Molina, Dora I.
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McKelvie, Robert
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Pogue, Janice
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Wilkinson, Joann ...
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Jung, Hyejung
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Dagenais, Gilles
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Yusuf, Salim
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New England Jour ...
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Uppsala universitet