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The rationale for t...
The rationale for targeting TGF-beta in chronic liver diseases
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- Giannelli, Gianluigi (författare)
- Univ Bari, Dept Biomed Sci & Human Oncol, Sch Med, Bari, Italy.
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- Mikulits, Wolfgang (författare)
- Med Univ Vienna, Ctr Comprehens Canc, Div Inst Canc Res, Dept Med 1, Vienna, Austria.
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- Dooley, Steven (författare)
- Mannheim Heidelberg Univ, Fac Med, Dept Med 2, Heidelberg, Germany.
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- Fabregat, Isabel (författare)
- Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain.
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- Moustakas, Aristidis (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Ludwiginstitutet för cancerforskning
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- ten Dijke, Peter (författare)
- Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Postbus 9600, NL-2300 RC Leiden, Netherlands.
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- Portincasa, Piero (författare)
- Univ Bari, Dept Biomed Sci & Human Oncol, Sch Med, Bari, Italy.
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- Winter, Peter (författare)
- GenXPro GmbH, Frankfurt, Germany.
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- Janssen, Richard (författare)
- Galapagos, Leiden, Netherlands.
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- Leporatti, Stefano (författare)
- CNR, NANOTEC Inst Nanotechnol, Lecce, Italy.
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- Herrera, Blanca (författare)
- Univ Complutense, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Bioquim & Biol Mol 2, E-28040 Madrid, Spain.
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- Sanchez, Aranzazu (författare)
- Univ Complutense, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Bioquim & Biol Mol 2, E-28040 Madrid, Spain.
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Univ Bari, Dept Biomed Sci & Human Oncol, Sch Med, Bari, Italy Med Univ Vienna, Ctr Comprehens Canc, Div Inst Canc Res, Dept Med 1, Vienna, Austria. (creator_code:org_t)
- 2016-03-12
- 2016
- Engelska.
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Ingår i: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 46:4, s. 349-361
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundTransforming growth factor (TGF)- is a pluripotent cytokine that displays several tissue-specific biological activities. In the liver, TGF- is considered a fundamental molecule, controlling organ size and growth by limiting hepatocyte proliferation. It is involved in fibrogenesis and, therefore, in worsening liver damage, as well as in triggering the development of hepatocellular carcinoma (HCC). TGF- is known to act as an oncosuppressor and also as a tumour promoter in HCC, but its role is still unclear. DesignIn this review, we discuss the potential role of TGF- in regulating the tumoural progression of HCC, and therefore the rationale for targeting this molecule in patients with HCC. ResultsA considerable amount of experimental preclinical evidence suggests that TGF- is a promising druggable target in patients with HCC. To support this hypothesis, a phase II clinical trial is currently ongoing using a TGF- pathway inhibitor, and results will soon be available. ConclusionsThe identification of new TGF- related biomarkers will help to select those patients most likely to benefit from therapy aimed at inhibiting the TGF- pathway. New formulations that may provide a more controlled and sustained delivery of the drug will improve the therapeutic success of such treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- EMT
- galunisertib
- HCC
- targeting TGF-beta RI
- TGF-beta
- tumour progression
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Giannelli, Gianl ...
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Mikulits, Wolfga ...
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Dooley, Steven
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Fabregat, Isabel
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Moustakas, Arist ...
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ten Dijke, Peter
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visa fler...
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Portincasa, Pier ...
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Winter, Peter
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Janssen, Richard
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Leporatti, Stefa ...
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Herrera, Blanca
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Sanchez, Aranzaz ...
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visa färre...
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