Sökning: onr:"swepub:oai:DiVA.org:uu-299698" > Simultaneous imagin...
Fältnamn | Indikatorer | Metadata |
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000 | 04274naa a2200517 4500 | |
001 | oai:DiVA.org:uu-299698 | |
003 | SwePub | |
008 | 160726s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133794214 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2996982 URI |
024 | 7 | a https://doi.org/10.1016/j.neuroimage.2016.05.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1337942142 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shariatgorji, Mohammadrezau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)mohsh560 |
245 | 1 0 | a Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry |
264 | 1 | b Elsevier BV,c 2016 |
338 | a print2 rdacarrier | |
520 | a With neurological processes involving multiple neurotransmitters and neuromodulators, it is important to have the ability to directly map and quantify multiple signaling molecules simultaneously in a single analysis. By utilizing a molecular-specific approach, namely desorption electrospray ionization mass spectrometry imaging (DESI-MSI), we demonstrated that the technique can be used to image multiple neurotransmitters and their metabolites (dopamine, dihydroxyphenylacetic acid, 3-methoxytyramine, serotonin, glutamate, glutamine, aspartate,gamma-aminobutyric acid, adenosine) as well as neuroactive drugs (amphetamine, sibutramine, fluvoxamine) and drug metabolites in situ directly in brain tissue sections. The use of both positive and negative ionization modes increased the number of identified molecular targets. Chemical derivatization by charge-tagging the primary amines of molecules significantly increased the sensitivity, enabling the detection of low abundant neurotransmitters and other neuroactive substances previously undetectable by MSI. The sensitivity of the imaging approach of neurochemicals has a great potential in many diverse applications in fields such as neuroscience, pharmacology, drug discovery, neurochemistry, and medicine. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
653 | a Neurotransmitter | |
653 | a Dopamine | |
653 | a Imaging | |
653 | a Mass spectrometry | |
653 | a Parkinson's disease | |
653 | a Serotonin | |
700 | 1 | a Strittmatter, Nicoleu AstraZeneca, Drug Safety & Metab, Cambridge CB4 0WG, England.4 aut |
700 | 1 | a Nilsson, Annau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)annil134 |
700 | 1 | a Kallbäck, Patriku Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)joaka138 |
700 | 1 | a Alvarsson, Alexandrau Karolinska Inst, Ctr Mol Med, Dept Neurol & Clin Neurosci, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Zhang, Xiaoqunu Karolinska Institutet4 aut |
700 | 1 | a Vallianatou, Theodosiau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)theva108 |
700 | 1 | a Svenningsson, Peru Karolinska Institutet4 aut |
700 | 1 | a Goodwin, Richard J. A.u AstraZeneca, Drug Safety & Metab, Cambridge CB4 0WG, England.4 aut |
700 | 1 | a Andrén, Per E.u Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)perandre |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t NeuroImaged : Elsevier BVg 136, s. 129-138q 136<129-138x 1053-8119x 1095-9572 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299698 |
856 | 4 8 | u https://doi.org/10.1016/j.neuroimage.2016.05.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133794214 |
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