Sökning: onr:"swepub:oai:DiVA.org:uu-299719" > Genetic basis of PD...
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000 | 06562naa a2200661 4500 | |
001 | oai:DiVA.org:uu-299719 | |
003 | SwePub | |
008 | 160726s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133775050 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2997192 URI |
024 | 7 | a https://doi.org/10.1182/blood-2015-12-6865502 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1337750502 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Georgiou, Konstantinosu Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.4 aut |
245 | 1 0 | a Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas |
264 | 1 | b American Society of Hematology,c 2016 |
338 | a print2 rdacarrier | |
520 | a Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Chen, Longyunu Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.4 aut |
700 | 1 | a Berglund, Mattiasu Karolinska Institutet4 aut |
700 | 1 | a Ren, Weichengu Karolinska Institutet4 aut |
700 | 1 | a de Miranda, Noel F. C. C.u Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.4 aut |
700 | 1 | a Lisboa, Susanau Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.4 aut |
700 | 1 | a Fangazio, Marcou Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut |
700 | 1 | a Zhu, Shidau BGI Shenzhen, Shenzhen, Peoples R China.4 aut |
700 | 1 | a Hou, Yongu BGI Shenzhen, Shenzhen, Peoples R China.4 aut |
700 | 1 | a Wu, Kuiu BGI Shenzhen, Shenzhen, Peoples R China.4 aut |
700 | 1 | a Fang, Wenfengu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut |
700 | 1 | a Wang, Xianhuou Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut |
700 | 1 | a Meng, Binu Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut |
700 | 1 | a Zhang, Liu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut |
700 | 1 | a Zeng, Yixinu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut |
700 | 1 | a Bhagat, Govindu Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.4 aut |
700 | 1 | a Nordenskjold, Magnusu Karolinska Institutet4 aut |
700 | 1 | a Sundström, Christeru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)chrisund |
700 | 1 | a Enblad, Gunillau Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)gunienbl |
700 | 1 | a Dalla-Favera, Riccardou Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut |
700 | 1 | a Zhang, Huilaiu Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.4 aut |
700 | 1 | a Teixeira, Manuel R.u Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.4 aut |
700 | 1 | a Pasqualucci, Laurau Columbia Univ, Inst Canc Genet, New York, NY USA.4 aut |
700 | 1 | a Peng, Roujunu Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.4 aut |
700 | 1 | a Pan-Hammarstrom, Qiangu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.b Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.4 org |
773 | 0 | t Bloodd : American Society of Hematologyg 127:24, s. 3026-3034q 127:24<3026-3034x 0006-4971x 1528-0020 |
856 | 4 | u https://ashpublications.org/blood/article-pdf/127/24/3026/1393975/3026.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299719 |
856 | 4 8 | u https://doi.org/10.1182/blood-2015-12-686550 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133775050 |
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