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c-Myb Enhances Brea...
c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/beta-Catenin/Axin2 Pathway
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- Li, Yihao (författare)
- Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands.
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- Jin, Ke (författare)
- Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
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- van Pelt, Gabi W. (författare)
- Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
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- van Dam, Hans (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning,Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands.
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- Yu, Xiao (författare)
- Leiden Univ, Med Ctr, Dept Anat & Embryol, Leiden, Netherlands.
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- Mesker, Wilma E. (författare)
- Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
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- ten Dijke, Peter (författare)
- Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands.;Uppsala Univ, Ludwig Inst Canc Res, Sci Life Lab, Uppsala, Sweden.
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- Zhou, Fangfang (författare)
- Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China.;Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R China.
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- Zhang, Long (författare)
- Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
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Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Leiden Univ, Med Ctr, Canc Genom Ctr Netherlands, Dept Mol Cell Biol, Leiden, Netherlands. Zhejiang Univ, Inst Life Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Univ, Innovat Ctr Cell Signaling Network, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 76:11, s. 3364-3375
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The molecular underpinnings of aggressive breast cancers remain mainly obscure. Here we demonstrate that activation of the transcription factor c-Myb is required for the prometastatic character of basal breast cancers. An analysis of breast cancer patients led us to identify c-Myb as an activator of Wnt/beta-catenin signaling. c-Myb interacted with the intracellular Wnt effector beta-catenin and coactivated the Wnt/beta-catenin target genes Cyclin D1 and Axin2. Moreover, c-Myb controlled metastasis in an Axin2-dependent manner. Expression microarray analyses revealed a positive association between Axin2 and c-Myb, a target of the proinflammatory cytokine IL1 beta that was found to be required for IL1 beta-induced breast cancer cell invasion. Overall, our results identified c-Myb as a promoter of breast cancer invasion and metastasis through its ability to activate Wnt/beta-catenin/Axin2 signaling. (C) 2016 AACR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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