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Multivariate projec...
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Mazzeo, Anna TeresaUniv Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.
(författare)
Multivariate projection method to investigate inflammation associated with secondary insults and outcome after human traumatic brain injury : a pilot study
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-06-21
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Springer Science and Business Media LLC,2016
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-299894
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299894URI
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https://doi.org/10.1186/s12974-016-0624-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Neuroinflammation has been proposed as a possible mechanism of brain damage after traumatic brain injury (TBI), but no consensus has been reached on the most relevant molecules. Furthermore, secondary insults occurring after TBI contribute to worsen neurological outcome in addition to the primary injury. We hypothesized that after TBI, a specific pattern of cytokines is related to secondary insults and outcome. Methods: A prospective observational clinical study was performed. Secondary insults by computerized multimodality monitoring system and systemic value of different cytokines were collected and analysed in the first week after intensive care unit admission. Neurological outcome was assessed at 6 months (GOSe). Multivariate projection technique was applied to analyse major sources of variation and collinearity within the cytokines dataset without a priori selecting potential relevant molecules. Results: Twenty-nine severe traumatic brain injury patients undergoing intracranial pressure monitoring were studied. In this pilot study, we demonstrated that after TBI, patients who suffered of prolonged and severe secondary brain damage are characterised by a specific pattern of cytokines. Patients evolving to brain death exhibited higher levels of inflammatory mediators compared to both patients with favorable and unfavorable neurological outcome at 6 months. Raised ICP and low cerebral perfusion pressure occurred in 21 % of good monitoring time. Furthermore, the principal components selected by multivariate projection technique were powerful predictors of neurological outcome. Conclusions: The multivariate projection method represents a valuable methodology to study neuroinflammation pattern occurring after secondary brain damage in severe TBI patients, overcoming multiple putative interactions between mediators and avoiding any subjective selection of relevant molecules.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Filippini, ClaudiaUniv Turin, Dept Surg Sci, Turin, Italy.
(författare)
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Rosato, RosalbaUniv Turin, Dept Psychol, Turin, Italy.
(författare)
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Fanelli, VitoUniv Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.
(författare)
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Assenzio, BarbaraUniv Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.
(författare)
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Piper, IanSo Gen Hosp, Dept Clin Phys, Glasgow, Lanark, Scotland.
(författare)
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Howells, TimothyUppsala universitet,Neurokirurgi(Swepub:uu)timho266
(författare)
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Mastromauro, IlariaUniv Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.
(författare)
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Berardino, MaurizioAOU Citta Salute & Sci Torino, Presidio CTO, Anesthesia & Intens Care Unit, Turin, Italy.
(författare)
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Ducati, AlessandroUniv Turin, Dept Neurosci, Neurosurg Unit, Turin, Italy.
(författare)
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Mascia, LucianaUniv Roma La Sapienza, Dipartimento Sci & Biotecnol Med Chirurg, Rome, Italy.
(författare)
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Univ Turin, Dept Surg Sci, Anesthesia & Intens Care Unit, Turin, Italy.Univ Turin, Dept Surg Sci, Turin, Italy.
(creator_code:org_t)
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Ingår i:Journal of Neuroinflammation: Springer Science and Business Media LLC131742-2094
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Mazzeo, Anna Ter ...
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Filippini, Claud ...
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Rosato, Rosalba
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Fanelli, Vito
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Assenzio, Barbar ...
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Piper, Ian
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visa fler...
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Howells, Timothy
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Mastromauro, Ila ...
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Berardino, Mauri ...
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Ducati, Alessand ...
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Mascia, Luciana
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Neurologi
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Journal of Neuro ...
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Uppsala universitet