Sökning: onr:"swepub:oai:DiVA.org:uu-301037" > Genome-wide associa...
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000 | 13868naa a2201093 4500 | |
001 | oai:DiVA.org:uu-301037 | |
003 | SwePub | |
008 | 160817s2016 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:44e94020-f867-4d82-818d-39eb100d6a67 | |
009 | oai:prod.swepub.kib.ki.se:133944603 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3010372 URI |
024 | 7 | a https://doi.org/10.1038/ncomms120502 DOI |
024 | 7 | a https://lup.lub.lu.se/record/44e94020-f867-4d82-818d-39eb100d6a672 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1339446032 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mitchell, Jonathan S.u Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
245 | 1 0 | a Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
264 | c 2016-07-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Li, Niu Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Weinhold, Nielsu Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.4 aut |
700 | 1 | a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,German Canc Res Ctr, D-69120 Heidelberg, Germany.;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.4 aut0 (Swepub:lu)med-asf |
700 | 1 | a Ali, Minau Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)med-ma16 |
700 | 1 | a van Duin, Marku Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.,Erasmus University Medical Center4 aut |
700 | 1 | a Thorleifsson, Gudmaru deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.,deCODE Genetics4 aut |
700 | 1 | a Johnson, David C.u Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England.,German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Chen, Bowangu German Canc Res Ctr, D-69120 Heidelberg, Germany.,German Cancer Research Centre4 aut |
700 | 1 | a Halvarsson, Britt-Marieu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)med-bhv |
700 | 1 | a Gudbjartsson, Daniel F.u deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland.4 aut |
700 | 1 | a Kuiper, Rowanu Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.,Erasmus University Medical Center4 aut |
700 | 1 | a Stephens, Owen W.u Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
700 | 1 | a Bertsch, Utau Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Broderick, Peteru Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Campo, Chiarau German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Einsele, Hermannu Univ Clin Wurzburg, D-97080 Wurzburg, Germany.4 aut |
700 | 1 | a Gregory, Walter A.u Univ Leeds, Clin Trials Res Unit, Leeds LS2 9PH, W Yorkshire, England.4 aut |
700 | 1 | a Gullberg, Urbanu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)efor-ugu |
700 | 1 | a Henrion, Marcu Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Hillengass, Jensu Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.4 aut |
700 | 1 | a Hoffmann, Peru Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Basel, Div Med Genet, Dept Biomed, CH-4003 Basel, Switzerland.4 aut |
700 | 1 | a Jackson, Graham H.u Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.4 aut |
700 | 1 | a Johnsson, Ellinoru Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)efor-ejo |
700 | 1 | a Jöud, Magnusu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Off Med Serv, Clin Immunol & Transfus Med, Lab Med, SE-22185 Lund, Sweden.4 aut0 (Swepub:lu)med-mjo |
700 | 1 | a Kristinsson, Sigurjdur Y.u Karolinska Institutet,Natl Univ Hosp Iceland, Dept Hematol, Landspitali, IS-101 Reykjavik, Iceland.4 aut |
700 | 1 | a Lenhoff, Stigu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.4 aut0 (Swepub:lu)med-slf |
700 | 1 | a Lenive, Olegu Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Mellqvist, Ulf-Henriku Sahlgrens Univ Hosp, Sect Hematol, S-41345 Gothenburg, Sweden.4 aut |
700 | 1 | a Migliorini, Gabrieleu Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Nahi, Harethu Karolinska Institutet,Karolinska Inst, Ctr Hematol & Regenerat Med, SE-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Nelander, Svenu Uppsala universitet,Neuroonkologi4 aut0 (Swepub:uu)svene843 |
700 | 1 | a Nickel, Jolantau Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.4 aut |
700 | 1 | a Nöthen, Markus M.u Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, D-53127 Bonn, Germany.4 aut |
700 | 1 | a Rafnar, Thorunnu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.4 aut |
700 | 1 | a Ross, Fiona M.u Univ Southampton, Wessex Reg Genet Lab, Salisbury SP2 8BJ, Wilts, England.4 aut |
700 | 1 | a da Silva Filho, Miguel Inaciou German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Swaminathan, Bhairaviu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)med-bvs |
700 | 1 | a Thomsen, Haukeu German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Turesson, Ingemaru Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.4 aut0 (Swepub:lu)medf-itu |
700 | 1 | a Vangsted, Annetteu Rigshosp, Univ Copenhagen Hosp, Dept Haematol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Vogel, Ullau Natl Res Ctr Working Environm, DK-2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Waage, Andersu Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Box 8905, N-7491 Trondheim, Norway.4 aut |
700 | 1 | a Walker, Brian A.u Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
700 | 1 | a Wihlborg, Anna-Karinu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.4 aut0 (Swepub:lu)kard-awi |
700 | 1 | a Broyl, Annemieku Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.4 aut |
700 | 1 | a Davies, Faith E.u Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
700 | 1 | a Thorsteinsdottir, Unnuru deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.4 aut |
700 | 1 | a Langer, Christianu Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany.4 aut |
700 | 1 | a Hansson, Markusu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Skane Univ Hosp, Hematol Clin, SE-22185 Lund, Sweden.4 aut0 (Swepub:lu)hema-mha |
700 | 1 | a Kaiser, Martinu Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England.4 aut |
700 | 1 | a Sonneveld, Pieteru Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.4 aut |
700 | 1 | a Stefansson, Kariu deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.4 aut |
700 | 1 | a Morgan, Gareth J.u Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.4 aut |
700 | 1 | a Goldschmidt, Hartmutu Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.4 aut |
700 | 1 | a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,German Canc Res Ctr, D-69120 Heidelberg, Germany.;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.4 aut0 (Swepub:lu)med-khk |
700 | 1 | a Nilsson, Björnu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Broad Institute,Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.;Off Med Serv, Clin Immunol & Transfus Med, Lab Med, SE-22185 Lund, Sweden.;Broad Inst, 7 Cambridge Ctr, Cambridge, MA 02142 USA.4 aut0 (Swepub:lu)klin-bni |
700 | 1 | a Houlston, Richard S.u Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.4 aut |
710 | 2 | a Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.b Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany.4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 7q 7x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/ncomms12050y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:953463/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/ncomms12050.pdf |
856 | 4 | u http://dx.doi.org/10.1038/ncomms12050x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301037 |
856 | 4 8 | u https://doi.org/10.1038/ncomms12050 |
856 | 4 8 | u https://lup.lub.lu.se/record/44e94020-f867-4d82-818d-39eb100d6a67 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133944603 |
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