Sökning: onr:"swepub:oai:DiVA.org:uu-302737" > Disrupting Reconsol...
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000 | 05102naa a2200505 4500 | |
001 | oai:DiVA.org:uu-302737 | |
003 | SwePub | |
008 | 160908s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:miun-38881 | |
009 | oai:prod.swepub.kib.ki.se:134394151 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3027372 URI |
024 | 7 | a https://doi.org/10.1016/j.cub.2016.08.0222 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-388812 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1343941512 URI |
040 | a (SwePub)uud (SwePub)miund (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Björkstrand, Johannesu Uppsala universitet,Institutionen för psykologi,Uppsala Universitet4 aut0 (Swepub:uu)johbj223 |
245 | 1 0 | a Disrupting Reconsolidation Attenuates Long-Term Fear Memory in the Human Amygdala and Facilitates Approach Behavior |
264 | 1 | b Elsevier BV,c 2016 |
338 | a print2 rdacarrier | |
520 | a Memories become labile and malleable to modification when recalled [1]. Fear-conditioning experiments in both rodents and humans indicate that amygdala-localized short-term fear memories can be attenuated by disruption of their reconsolidation with extinction training soon after memory activation [2-7]. However, this may not be true for natural long-term fears. Studies in rodents indicate that although it is possible to disrupt the reconsolidation of older memories [8-11], they appear to be more resistant [1, 3, 9, 12, 13]. In humans, 1-week-old conditioned fear memories have been attenuated by behaviorally induced disruption of reconsolidation [14], but it remains to be seen whether this is possible for naturally occurring long-term fears and whether the underlying neural mechanisms are similar to those found in experimental fear-conditioning paradigms. Using functional brain imaging in individuals with a lifelong fear of spiders, we show that fear memory activation followed by repeated exposure to feared cues after 10 min, which disrupts reconsolidation, attenuates activity in the basolateral amygdala at re-exposure 24 hr later. In contrast, repeated exposure 6 hr after fear memory activation, which allows for reconsolidation, did not attenuate amygdala activity. Disrupted, but not undisrupted, reconsolidation facilitated approach behavior to feared cues, and approach behavior was inversely related to amygdala activity during re-exposure. We conclude that memory activation immediately preceding exposure attenuates the neural and behavioral expression of decades-old fear memories and that, similar to experimentally induced fear memories, the basolateral amygdala is crucially involved in this process. | |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Ågren, Thomasu Uppsala universitet,Institutionen för psykologi,Uppsala Universitet4 aut0 (Swepub:uu)thoag299 |
700 | 1 | a Åhs, Fredriku Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden,Uppsala Universitet; Karolinska Institutet4 aut0 (Swepub:miun)freahs |
700 | 1 | a Frick, Andreasu Uppsala universitet,Institutionen för psykologi,Uppsala Universitet4 aut0 (Swepub:uu)andfr548 |
700 | 1 | a Larsson, Elna-Marieu Uppsala universitet,Radiologi,Uppsala Universitet4 aut0 (Swepub:uu)elnla305 |
700 | 1 | a Hjorth, Olofu Uppsala universitet,Institutionen för psykologi,Uppsala Universitet4 aut0 (Swepub:uu)olohj176 |
700 | 1 | a Furmark, Tomasu Uppsala universitet,Institutionen för psykologi,Uppsala Universitet4 aut0 (Swepub:uu)tomafurm |
700 | 1 | a Fredrikson, Matsu Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden,Uppsala Universitet; Karolinska Institutet4 aut0 (Swepub:uu)matsfred |
710 | 2 | a Uppsala universitetb Institutionen för psykologi4 org |
773 | 0 | t Current Biologyd : Elsevier BVg 26:19, s. 2690-95q 26:19<2690-95x 0960-9822x 1879-0445 |
856 | 4 | u http://www.cell.com/article/S0960982216309344/pdf |
856 | 4 | u https://doi.org/10.1016/j.cub.2016.08.022y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302737 |
856 | 4 8 | u https://doi.org/10.1016/j.cub.2016.08.022 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38881 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134394151 |
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