Sökning: onr:"swepub:oai:DiVA.org:uu-303737" > Cystatin C and Card...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 15442naa a2201345 4500 | |
001 | oai:DiVA.org:uu-303737 | |
003 | SwePub | |
008 | 160923s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134089247 | |
009 | oai:DiVA.org:du-23629 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3037372 URI |
024 | 7 | a https://doi.org/10.1016/j.jacc.2016.05.0922 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1340892472 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-236292 URI |
040 | a (SwePub)uud (SwePub)kid (SwePub)du | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van der Laan, Sander W.u Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.4 aut |
245 | 1 0 | a Cystatin C and Cardiovascular Disease :b A Mendelian Randomization Study |
264 | 1 | b Elsevier BV,c 2016 |
338 | a electronic2 rdacarrier | |
500 | a De två första författarna delar förstaförfattarskapet. | |
520 | a BACKGROUND Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. OBJECTIVES The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. METHODS We incorporated participant data from 16 prospective cohorts (n = 76,481) with 37,126 measures of cystatin C and added genetic data from 43 studies (n = 252,216) with 63,292 CVD events. We used the common variant rs911119 in CST3 as an instrumental variable to investigate the causal role of cystatin C in CVD, including coronary heart disease, ischemic stroke, and heart failure. RESULTS Cystatin C concentrations were associated with CVD risk after adjusting for age, sex, and traditional risk factors (relative risk: 1.82 per doubling of cystatin C; 95% confidence interval [CI]: 1.56 to 2.13; p = 2.12 x 10(-14)). The minor allele of rs911119 was associated with decreased serum cystatin C (6.13% per allele; 95% CI: 5.75 to 6.50; p = 5.95 x 10(-211)), explaining 2.8% of the observed variation in cystatin C. Mendelian randomization analysis did not provide evidence fora causal role of cystatin C, with a causal relative risk for CVD of 1.00 per doubling cystatin C (95% CI: 0.82 to 1.22; p = 0,994), which was statistically different from the observational estimate (p = 1.6 x 10(-5)). A causal effect of cystatin C was not detected for any individual component of CVD. CONCLUSIONS Mendelian randomization analyses did not support a causal role of cystatin C in the etiology of CVD. As such, therapeutics targeted at lowering circulating cystatin C are unlikely to be effective in preventing CVD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a coronary heart disease | |
653 | a genetics | |
653 | a heart failure | |
653 | a ischemic stroke | |
653 | a Hälsa och välfärd | |
700 | 1 | a Fall, Toveu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878 |
700 | 1 | a Soumare, Aichau Univ Bordeaux, INSERM, U1219, Team Vintage, Bordeaux, France.4 aut |
700 | 1 | a Teumer, Alexanderu Univ Med Greifswald, Inst Community Med, Dept SHIP KEF, Greifswald, Germany.;German Ctr Cardiovasc Res, DZHK, Partner Site, Greifswald, Germany.4 aut |
700 | 1 | a Sedaghat, Sanazu Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.,UCL, Inst Cardiovasc Sci, Genet Epidemiol Res Grp, London, England.;Barts Heart Ctr, London, England.;UCL, Farr Inst Hlth Informat, London, England.4 aut |
700 | 1 | a Baumert, Jensu German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Zabaneh, Delilahu UCL, Dept Genet Environm & Evolut, London, England.;UCL, Genet Inst, London, England.4 aut |
700 | 1 | a van Setten, Jessicau Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.4 aut |
700 | 1 | a Isgum, Ivanau Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands.,Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, Utrecht, Netherlands.4 aut |
700 | 1 | a Galesloot, Tessel E.u Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.4 aut |
700 | 1 | a Arpegard, Johannesu Karolinska Univ Hosp Solna, Dept Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.4 aut |
700 | 1 | a Amouyel, Philippeu Univ Lille, INSERM, Lille, France.;Inst Pasteur, Lille, France.4 aut |
700 | 1 | a Trompet, Stellau Leiden Univ, Med Ctr, Dept Cardiol P C5, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands.4 aut |
700 | 1 | a Waldenberger, Melanieu German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.4 aut |
700 | 1 | a Doerr, Marcusu German Ctr Cardiovasc Res, DZHK, Partner Site, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.4 aut |
700 | 1 | a Magnusson, Patrik K.u Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut |
700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
700 | 1 | a Larsson, Andersu Uppsala universitet,Biokemisk struktur och funktion,Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.4 aut0 (Swepub:uu)andlarss |
700 | 1 | a Morris, Andrew P.u Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut |
700 | 1 | a Felix, Janine F.u Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut |
700 | 1 | a Morrison, Alanna C.u Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.4 aut |
700 | 1 | a Franceschini, Norau Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.4 aut |
700 | 1 | a Bis, Joshua C.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut |
700 | 1 | a Kavousi, Maryamu Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut |
700 | 1 | a O'Donnell, Christopheru Boston Vet Adm Healthcare, Dept Cardiol, West Roxbury, MA USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.4 aut |
700 | 1 | a Drenos, Fotiosu UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England.;Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England.4 aut |
700 | 1 | a Tragante, Viniciusu Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.4 aut |
700 | 1 | a Munroe, Patricia B.u Queen Mary Univ London, William Harvey Res Inst, Natl Inst Hlth Res, Cardiovasc Biomed Res Unit, London, England.4 aut |
700 | 1 | a Malik, Raineru Univ Munich, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany.4 aut |
700 | 1 | a Dichgans, Martinu Univ Munich, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany.;Munich Cluster Syst Neurol SyNergy, Munich, Germany.4 aut |
700 | 1 | a Worrall, Bradford B.u Univ Virginia, Dept Neurol, Charlottesville, VA USA.;Univ Virginia, Dept Hlth Evaluat Sci, Charlottesville, VA USA.4 aut |
700 | 1 | a Erdmann, Jeanetteu Univ Lubeck, Inst Integrat & Expt Genom, Lubeck, Germany.4 aut |
700 | 1 | a Nelson, Christopher P.u Univ Leicester, Glenfield Hosp, British Heart Fdn Cardiovasc, Res Ctr,Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res Leicester, Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut |
700 | 1 | a Samani, Nilesh J.u Univ Leicester, Glenfield Hosp, British Heart Fdn Cardiovasc, Res Ctr,Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res Leicester, Cardiovasc Biomed Res Unit, Leicester, Leics, England.4 aut |
700 | 1 | a Schunkert, Heribertu Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;German Ctr Cardiovasc Res, DZHK, Munich Heart Alliance, Partner Site, Munich, Germany.4 aut |
700 | 1 | a Marchini, Jonathanu Univ Oxford, Dept Stat, Oxford, England.4 aut |
700 | 1 | a Patel, Riyaz S.u Karolinska Institutet4 aut |
700 | 1 | a Hingorani, Aroon D.u UCL, Inst Cardiovasc Sci, Genet Epidemiol Res Grp, London, England.4 aut |
700 | 1 | a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut0 (Swepub:uu)larslind |
700 | 1 | a Pedersen, Nancy L.u Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut |
700 | 1 | a de Graaf, Jacquelineu Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands.4 aut |
700 | 1 | a Kiemeney, Lambertus A. L. M.u Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands.4 aut |
700 | 1 | a Baumeister, Sebastian E.u Univ Med Greifswald, Inst Community Med, Dept SHIP KEF, Greifswald, Germany.;Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany.4 aut |
700 | 1 | a Franco, Oscar H.u Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut |
700 | 1 | a Hofman, Albertu Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut |
700 | 1 | a Uitterlinden, Andre G.u Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands.4 aut |
700 | 1 | a Koenig, Wolfgangu German Ctr Cardiovasc Res, DZHK, Partner Site, Greifswald, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany.4 aut |
700 | 1 | a Meisinger, Christau German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Peters, Annetteu German Ctr Cardiovasc Res, DZHK, Partner Site, Greifswald, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Thorand, Barbarau German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Jukema, J. Wouteru Leiden Univ, Med Ctr, Dept Cardiol P C5, Leiden, Netherlands.;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.4 aut |
700 | 1 | a Eriksen, Bjorn Odvaru UiT Arctic Univ Norway, Metab & Renal Res Grp, Tromso, Norway.;Univ Hosp North Norway, Nephrol Sect, Tromso, Norway.4 aut |
700 | 1 | a Toft, Ingridu Univ Hosp North Norway, Nephrol Sect, Tromso, Norway.4 aut |
700 | 1 | a Wilsgaard, Tomu UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.4 aut |
700 | 1 | a Onland-Moret, N. Charlotteu Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut |
700 | 1 | a van der Schouw, Yvonne T.u Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut |
700 | 1 | a Debette, Stephanieu Univ Bordeaux, INSERM, U1219, Team Vintage, Bordeaux, France.4 aut |
700 | 1 | a Kumari, Meenau Univ Essex, Biol & Social Epidemiol, Inst Social & Econ Res, Colchester CO4 3SQ, Essex, England.4 aut |
700 | 1 | a Svensson, Peru Karolinska Univ Hosp Solna, Dept Emergency Med, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.4 aut |
700 | 1 | a van der Harst, Pimu ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.4 aut |
700 | 1 | a Kivimaki, Mikau UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut |
700 | 1 | a Keating, Brendan J.u Univ Penn, Dept Surg, Div Transplantat, Perelman Sch Med, Philadelphia, PA 19104 USA.4 aut |
700 | 1 | a Sattar, Naveedu Univ Glasgow, Glasgow, Lanark, Scotland.4 aut |
700 | 1 | a Dehghan, Abbasu Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.4 aut |
700 | 1 | a Reiner, Alex P.u Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)ering425 |
700 | 1 | a den Ruijter, Hester M.u Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.4 aut |
700 | 1 | a de Bakker, Paul I. W.u Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, Utrecht, Netherlands.4 aut |
700 | 1 | a Pasterkamp, Gerardu Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.;Univ Med Ctr Utrecht, Div Labs & Pharm, Lab Clin Chem & Hematol, Utrecht, Netherlands.4 aut |
700 | 1 | a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Kardiovaskulär epidemiologi,Medicinsk vetenskap,Uppsala university4 aut0 (Swepub:du)jan |
700 | 1 | a Holmes, Michael V.u Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Richard Doll Bldg,Old Rd Campus,Roosevelt Dr, Oxford OX3 7LF, England.4 aut |
700 | 1 | a Asselbergs, Folkert W.u Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.;UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England.4 aut |
710 | 2 | a Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.b Molekylär epidemiologi4 org |
773 | 0 | t Journal of the American College of Cardiologyd : Elsevier BVg 68:9, s. 934-945q 68:9<934-945x 0735-1097x 1558-3597 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:973929/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.jacc.2016.05.092 |
856 | 4 | u https://doi.org/10.1016/j.jacc.2016.05.092y Fulltext |
856 | 4 | u https://du.diva-portal.org/smash/get/diva2:1058062/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303737 |
856 | 4 8 | u https://doi.org/10.1016/j.jacc.2016.05.092 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134089247 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-23629 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy