Sökning: onr:"swepub:oai:DiVA.org:uu-305956" >
Using the Disease S...
Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease
-
- Munoz-Ruiz, Miguel Angel (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
-
- Hall, Anette (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
-
- Mattila, Jussi (författare)
- VTT Tech Res Ctr Finland, Tampere, Finland.
-
visa fler...
-
- Koikkalainen, Juha (författare)
- VTT Tech Res Ctr Finland, Tampere, Finland.
-
- Herukka, Sanna-Kaisa (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
-
- Husso, Minna (författare)
- Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
-
- Hanninen, Tuomo (författare)
- Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
-
- Vanninen, Ritva (författare)
- Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
-
- Liu, Yawu (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Radiol, Kuopio, Finland.
-
- Hallikainen, Merja (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.
-
- Lotjonen, Jyrki (författare)
- VTT Tech Res Ctr Finland, Tampere, Finland.
-
- Remes, Anne M. (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
-
- Alafuzoff, Irina (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Univ Uppsala Hosp, Rudbeck Lab, Dept Clin Surg Pathol, Uppsala, Sweden.
-
- Soininen, Hilkka (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
-
- Hartikainen, Paivi (författare)
- Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland.
-
visa färre...
-
Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland VTT Tech Res Ctr Finland, Tampere, Finland. (creator_code:org_t)
- 2016-07-22
- 2016
- Engelska.
-
Ingår i: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 6:2, s. 313-329
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.karger.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. Aims: To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). Methods: The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases. We utilized data from neuropsychological tests, volumetric magnetic resonance imaging, single-photon emission tomography, cerebrospinal fluid biomarkers and the APOE genotype. The DSI classification results were calculated with a combination of leave-one-out cross-validation and bootstrapping. A DSF visualization of a FTD patient is presented as an example. Results: The DSI distinguishes controls from FTD (area under the receiver-operator curve, AUC = 0.99) and AD (AUC = 1.00) very well and achieves a good differential diagnosis between AD and FTD (AUC = 0.89). In subsamples of autopsy-confirmed cases (AUC = 0.97) and clinically diagnosed cases (AUC = 0.94), differential diagnosis of AD and FTD performs very well. Conclusions: DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases. Here, DSI separates controls from dementia and differentiates between AD and FTD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- Frontotemporal dementia
- Computer-assisted diagnosis
- Magnetic resonance imaging
- Neuropsychology
- Single-photon emission tomography
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Munoz-Ruiz, Migu ...
-
Hall, Anette
-
Mattila, Jussi
-
Koikkalainen, Ju ...
-
Herukka, Sanna-K ...
-
Husso, Minna
-
visa fler...
-
Hanninen, Tuomo
-
Vanninen, Ritva
-
Liu, Yawu
-
Hallikainen, Mer ...
-
Lotjonen, Jyrki
-
Remes, Anne M.
-
Alafuzoff, Irina
-
Soininen, Hilkka
-
Hartikainen, Pai ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Dementia and Ger ...
- Av lärosätet
-
Uppsala universitet