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Comparison of Dabig...
Comparison of Dabigatran and Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulant Therapy)
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- Ezekowitz, Michael D. (författare)
- Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.;Cardiovasc Res Fdn, New York, NY USA.
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- Nagarakanti, Rangadham (författare)
- Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ USA.;Electrophysiol Res Fdn, Warren, NJ USA.
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- Noack, Herbert (författare)
- Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
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- Brueckmann, Martina (författare)
- Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.;Heidelberg Univ, Fac Med Mannheim, Mannheim, Germany.
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- Litherland, Claire (författare)
- Cardiovasc Res Fdn, New York, NY USA.
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- Jacobs, Mark (författare)
- Albert Einstein Coll Med, New York, NY USA.
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- Clemens, Andreas (författare)
- Univ Med Ctr Mainz, Ctr Thrombosis & Hemostasis, Mainz, Germany.
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- Reilly, Paul A. (författare)
- Boehringer Ingelheim Pharmaceut Inc, 90 E Ridge POB 368, Ridgefield, CT 06877 USA.
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- Connolly, Stuart J. (författare)
- McMaster Univ, Hamilton, ON, Canada.
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- Yusuf, Salim (författare)
- McMaster Univ, Hamilton, ON, Canada.
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- Wallentin, Lars (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA;Cardiovasc Res Fdn, New York, NY USA. Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ USA.;Electrophysiol Res Fdn, Warren, NJ USA. (creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Circulation. - 0009-7322 .- 1524-4539. ; 134:8, s. 589-598
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The RE-LY trial (Randomized Evaluation of Long-Term Anticoagulant Therapy) compared dabigatran 150 and 110 mg twice daily with warfarin in 18 113 patients with atrial fibrillation. Those with prosthetic heart valves, significant mitral stenosis, and valvular heart disease (VHD) requiring intervention were excluded. Others with VHD were included. METHODS: This is a post hoc analysis of the RE-LY trial. RESULTS: There were 3950 patients with any VHD: 3101 had mitral regurgitation, 1179 with tricuspid regurgitation, 817 had aortic regurgitation, 471 with aortic stenosis, and 193 with mild mitral stenosis. At baseline, patients with any VHD had more heart failure, coronary disease, renal impairment, and persistent atrial fibrillation. Patients with any VHD had higher rates of major bleeds (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.16-1.5) but similar stroke or systemic embolism event rates (HR, 1.09; 95% CI, 0.88-1.33). For patients receiving dabigatran 110 mg, major bleed rates were lower than for patients taking warfarin (HR, 0.73; 95% CI, 0.56-0.95 with VHD; HR, 0.84; 95% CI, 0.71-0.99 without VHD), and major bleed rates for dabigatran 150 mg were similar to those for warfarin in patients with VHD (HR, 0.82; 95% CI, 0.64-1.06) or without VHD (HR, 0.98; 95% CI, 0.83-1.15). For dabigatran 150 mg, stroke/systemic embolic event rates were lower compared with warfarin in those with VHD (HR, 0.59; 95% CI, 0.37-0.93) and those without VHD (HR, 0.67; 95% CI, 0.52-0.86), and stroke/systemic embolic event rates were similar for warfarin and dabigatran 110 mg regardless of the presence of VHD (HR, 0.97; 95% CI, 0.65-1.45; and HR, 0.88; 95% CI, 0.70-1.10). Intracranial bleeds and death rates for dabigatran 150 and 110 mg were lower compared with warfarin independently of the presence of VHD. CONCLUSIONS: The presence of any VHD did not influence the comparison of dabigatran with warfarin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atrial fibrillation
- stroke
- valvular heart diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Ezekowitz, Micha ...
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Nagarakanti, Ran ...
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Noack, Herbert
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Brueckmann, Mart ...
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Litherland, Clai ...
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Jacobs, Mark
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Clemens, Andreas
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Reilly, Paul A.
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Connolly, Stuart ...
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Yusuf, Salim
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Wallentin, Lars
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Circulation
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Uppsala universitet